Platelet endothelial cell adhesion molecule, PECAM-1, EndoCAM, GPIIA', CD31 antigen, PECAM1, CD31.

Mouse Anti Human Monoclonal.

CD31 is a glycoprotein expressed on endothelial cells, platelets, macrophages and Kupffer cells, granulocytes, T / NK cells, lymphocytes, megakaryocytes, fibroblasts, osteoclasts, neutrophils. In humans, the gene encoding CD31 is found on chromosome 17.
CD31 is a cluster of differentiation molecule. It is also called PECAM-1 for platelet endothelial cell adhesion molecule. It plays a key role in removing aged neutrophils from the body. Both the neutrophil and the macrophage express CD31 on their membranes, and during the testing process, these CD31 molecules bind the two cells together. If the neutrophil is healthy, it will send a signal to the macrophage, and the CD31 molecules will detach.
CD31 is also expressed in certain tumors, including epithelioid hemangioendothelioma, epithelioid sarcoma-like hemangioendothelioma, other vascular tumors, histiocytic malignancies, and plasmacytomas. It is rarely found in some sarcomas and carcinomas.

hCD31

Enriched human platelets

mouse IgG1

Antibody is shipped lyophilized at ambient temperature.

In lyophilized form, for long periods, store at 4°C in a dry environment. After reconstitution,
if not intended for use within a month, aliquot and store at -20°C.

Reconstitute with H₂0. Mix gently, wash the sides of the vial and wait 30-60 seconds before use.

Flow cytometry, immunohistochemistry. For staining, use 10μl/10⁶ cells.

This antibody is also available conjugated to FITC and biotin. For flow cytometry use 5-10μl/10⁶ cells.

CD31 is expressed in high levels on endothelial cells and in lower levels on monocytes, granulocytes and platelets.

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.