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產(chǎn)品名稱: CD45RC Antibody (APC)
產(chǎn)品型號: abx200337
產(chǎn)品展商: 其他品牌
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
CD45RC Antibody (APC)
的詳細介紹
This antibody reacts with CD45RC on pre-B lymphocytes,B cells,CD8+ T suppressor/cytotoxic cells,and a subset of CD4+ T helper (Th)lymphocytes. It weakly reacts with thymocytes.4 CD45RC is a high-molecular-weight isoform of CD45 (Leukocyte Common Antigen);its level of expression distinguishes subpopulations of CD4 +T cells with Th1-like and Th2-like effector functions. Levels of expression of CD45RC have also been reported to distinguish resting from activated T cells at various stages of maturation. CD45 is a member of the Protein Tyrosine Phosphatase (PTP)family:Its intracellular (COOH-terminal)region contains two PTP catalytic domains,and the extracellular region is highly variable due to alternative splicing of exons 4,5,and 6 (designated A,B,and C,respectively),plus differing levels of glycosylation. The CD45 isoforms detected in the rat are cell type-,maturation-,and activation state-specific. The CD45 isoforms play complex roles in T-cell and B-cell antigen receptor signal transduction.
| Target |
CD45RC |
| Reactivity |
Human |
| Host |
Mouse |
| Clonality |
Monoclonal |
| Tested Applications |
FCM |
| Recommended dilutions |
FCM: 20 μl/1 million cells. Optimal dilutions/concentrations should be determined by the end user. |
| Immunogen |
Cells CD45+ of healtly donors. |
| Purification |
Affinity Chromatography |
| Form |
Liquid |
| Isotype |
IgG1 |
| Conjugation |
APC |
| Specificity |
It is used for the differential diagnosis of nonHodgkin lymphomas. It also reacts with T suppressor/cytotoxic cells and NK cells.Their functional activity may be related to the induction of suppressor or cytotoxic activity, and activation processes. |
| Storage |
Store in the dark at 2-8 °C. |
| Molecular Weight |
220 kDa |
| Swiss Prot |
P08575
|
| GeneID |
5788
|
| Enzyme Commission Number |
EC 3.1.3.4 |
| Buffer |
The reagent is provided in aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium Azide |
| UNSPSC Code |
12352203 |
| Availability |
Shipped within 2-3 weeks. |
| Note |
This product is for research use only. |
