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產(chǎn)品名稱(chēng): CD49d Antibody (FITC)
產(chǎn)品型號(hào): abx200352
產(chǎn)品展商: 其他品牌
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簡(jiǎn)單介紹
CD49d Antibody (FITC)
的詳細(xì)介紹
The CD29 antigen, also known as the ?-1 subunit, is common to the VLA family of integrins. When acting as a matrix receptor, the CD49d antigen binds to CS-1, an alternatively spliced domain of fibronectin. When functioning as a cell receptor, the CD49d antigen binds to the vascular cell-adhesion molecule-1 (VCAM-1). The interaction between the CD49d antigen and VCAM-1 is known to play an important role in stabilizing the adhesion of lymphocytes to endothelial cells and in mediating B-lymphocyte precursor/bone marrow stromal cell adhesion. The CD49d antigen, when associated with the ? integrin, forms a lymphocyte homing receptor for Peyer's patch, binding tothe mucosal vascular addressin MAdCAM-1. The CD49d antigen is also involved in CD3-dependent CD4+ T-lymphocyte activation via its interaction with fibronectin.
| Target |
CD49d |
| Reactivity |
Human |
| Host |
Mouse |
| Clonality |
Monoclonal |
| Tested Applications |
FCM |
| Recommended dilutions |
FCM: 20 μl/1 million cells. Optimal dilutions/concentrations should be determined by the end user. |
| Immunogen |
Tissue / cell preparation (JM leukemia line). |
| Purification |
Affinity Chromatography |
| Form |
Liquid |
| Isotype |
IgG1 |
| Conjugation |
FITC |
| Specificity |
CD49d (Anti–VLA-α-4) recognizes the 150-kilodalton (kd) α-chain of very-late antigen (VLA)-4, a member of the integrin family of cell adhesion molecules. VLA-4, like other integrins, is a noncovalently associated heterodimeric glycoprotein composed of α and ? subunits and is involved in cell–cell and cell–extracellular matrix interactions. The ?-chain of the VLA-4 complex is the CD29 antigen, a 130-kd glycoprotein. |
| Storage |
Store in the dark at 2-8 °C. |
| Molecular Weight |
150 kDa |
| Swiss Prot |
P13612
|
| GeneID |
3676
|
| Buffer |
The reagent is provided in aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium Azide |
| UNSPSC Code |
12352203 |
| Availability |
Shipped within 3-5 working days. |
| Note |
This product is for research use only. |
