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產(chǎn)品名稱: CD49c Antibody (FITC)
產(chǎn)品型號: abx200346
產(chǎn)品展商: 其他品牌
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
CD49c Antibody (FITC)
的詳細(xì)介紹
Reacts with α 3 integrin, a 150 kDa transmembrane glycoprotein which non-covalently associates with integrin b 1 (CD 29) to form the α 3b1 (CD49c/CD29,VLA-3) complex. CD49c is expressed mostly on endothelial and epithelial cells (basal epidermal layers). It is not expressed on platelets and is expressed weakly on peripheral blood leukocytes. The CD49c/CD29 complex serves as an adhesive receptor for kalinin or epiligrin. This interaction may be important for thymocyte interaction with thymic epithelium. This antibody is suitable for immunohistochemical staining on acetone-fixed frozen tissue sections.1-3
| Target |
CD49c |
| Reactivity |
Human |
| Host |
Mouse |
| Clonality |
Monoclonal |
| Tested Applications |
FCM |
| Recommended dilutions |
FCM: 20 μl/1 million cells. Optimal dilutions/concentrations should be determined by the end user. |
| Immunogen |
Integrin alpha 3. |
| Purification |
Affinity Chromatography |
| Form |
Liquid |
| Isotype |
IgG1 |
| Conjugation |
FITC |
| Specificity |
It is a type I transmembrane glycoprotein which is proteolytically cleaved into two disulfide linked fragments of 125 kD and 30 kD. CD49c forms a heterodimer with integrin b1 (α3b1, CD49c/CD29, VLA-3) and is expressed by many types of adhesion cells, such as endothelial cells, epithelial cells, and dermal fibroblasts. Weak expression has been reported on leukocytes. VLA-3 plays a role in cell-cell and cell-matrix adhesion through binding Kalinin, collagen, laminin-1, laminin-5, entactin, and fibronectin. |
| Storage |
Store in the dark at 2-8 °C. |
| Molecular Weight |
150 kDa |
| Swiss Prot |
P26006
|
| GeneID |
3675
|
| Buffer |
The reagent is provided in aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium Azide |
| UNSPSC Code |
12352203 |
| Availability |
Shipped within 2-3 weeks. |
| Note |
This product is for research use only. |
