Caspase 3 active Antibody
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產(chǎn)品名稱: Caspase 3 active Antibody
產(chǎn)品型號(hào): abx200557
產(chǎn)品展商: 其他品牌
產(chǎn)品文檔: 無(wú)相關(guān)文檔
簡(jiǎn)單介紹
Caspase 3 active Antibody
的詳細(xì)介紹
Caspase 3 active Antibody is a Rabbit Polyclonal against Caspase 3 active. Caspases are a family of cytosolic aspartate specific cysteine proteases involved in apoptosis and inflammation. Caspase-3 (CPP-32, Apoptain, Yama, SCA-1) is a key protease that is activated during the early stages of apoptosis, as it is either partially or totally responsible for the proteolytic cleavage of many key proteins during apoptosis, such as ply (APD-ribose) polymerase (PARP). The processed form of Caspase 3 consists of large (17kDa) and small (12kDa) subunits which is derived from the 32 kDa proenzyme and associate to form an active enzyme. Caspase 3 is cleaved at Asp28 Ser29 and Asp175 Ser176. The active Caspase 3 proteolytically cleaves and activates other caspases (e.g. Caspases 6, 7 and 9).
| Target |
Caspase 3 active |
| Reactivity |
Human |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Tested Applications |
WB |
| Recommended dilutions |
WB: 1/3000. Optimal dilutions/concentrations should be determined by the end user. |
| Immunogen |
Synthetic peptide (KLH-conjugated) corresponding to amino terminal residues adjacent to Asp175 of human caspase-3. |
| Purity |
> 90% |
| Conjugation |
Unconjugated |
| Specificity |
The antibody preferentially recognizes the p17 fragment of the active Caspase-3, and Cleaved Caspase-3 (Asp175). |
| Storage |
Aliquoted and store in the dark at - 20 °C. Avoidrepeated freeze/thaw cycles. |
| Molecular Weight |
17 kDa |
| Swiss Prot |
P42574
|
| GeneID |
836
|
| Concentration |
3 mg/ml |
| Buffer |
20 mM PBS, 150 mM CINa, pH 7.2, 0.09% sodium azide. Does not contain BSA. |
| Availability |
Shipped within 3-5 working days. |
| Note |
This product is for research use only. |
