Calcium-Transporting ATPase Type 2C Member 1 (ATP2C1) Antibody
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產(chǎn)品名稱: Calcium-Transporting ATPase Type 2C Member 1 (ATP2C1) Antibody
產(chǎn)品型號: abx010431
產(chǎn)品展商: 其他品牌
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簡單介紹
Calcium-Transporting ATPase Type 2C Member 1 (ATP2C1) Antibody
Calcium-Transporting ATPase Type 2C Member 1 (ATP2C1) Antibody
的詳細介紹
ATP2C1, also known as PMR1, it belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium. The human homologue, ATP2C1 (also designated SPLA in rat), also regulates the transport of calcium in the Golgi complex and is related to other P-type ATPases family members, such as the sarco (endo)plasmic calcium ATPase (SERCA) and the plasma membrane calcium ATPase (PCMA). ATP2C1 is a transmembrane protein that exists as two splice variants, which vary by 20 amino acids. Defects in ATP2C1 cause Hailey-Hailey disease, which is an autosomal dominant disorder that is characterized by blisters and erosions of the skin. These findings provide further evidence that PMR1 plays a key role in maintaining the integrity of the epidermis by controlling intracellular calcium signaling.
| Target |
Calcium-Transporting ATPase Type 2C Member 1 (ATP2C1) |
| Reactivity |
Human, Monkey |
| Host |
Mouse |
| Clonality |
Monoclonal |
| Tested Applications |
ELISA, WB, IHC |
| Recommended dilutions |
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Immunogen |
Purified recombinant fragment of ATP2C1 expressed in E. Coli. |
| Purification |
Unpurified Ascites. |
| Isotype |
IgG1 |
| Conjugation |
Unconjugated |
| Storage |
Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Molecular Weight |
100 kDa |
| Swiss Prot |
P98194
|
| GeneID |
27032
|
| Buffer |
Ascitic fluid containing 0.03% sodium azide. |
| UNSPSC Code |
12352203 |
| Availability |
Shipped within 5-10 working days. |
| Note |
This product is for research use only. |
