Breast Cancer Anti-Estrogen Resistance Protein 3 (BCAR3) Antibody
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產(chǎn)品名稱: Breast Cancer Anti-Estrogen Resistance Protein 3 (BCAR3) Antibody
產(chǎn)品型號(hào): abx010337
產(chǎn)品展商: 其他品牌
產(chǎn)品文檔: 無(wú)相關(guān)文檔
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Breast Cancer Anti-Estrogen Resistance Protein 3 (BCAR3) Antibody
Breast Cancer Anti-Estrogen Resistance Protein 3 (BCAR3) Antibody
的詳細(xì)介紹
BCAR3 Antibody detects endogenous levels of BCAR3. A ubiquitously expressed regulator of R-Ras activity that has been implicated in breast cancer. A GDP exchange factor whose overexpression confers antiestrogen resistance, activates Rac, PAK1, and the cyclin D1. Can accelerate the degradation of IRS-1, thus regulating signaling through the insulin receptor. When overexpressed, it confers anti-estrogen resistance in breast cancer cell lines. May also be regulated by cellular adhesion to extracellular matrix proteins. Up-regulated by interleukin-1-alpha and TNF-beta in thymus cortical reticular cell lines (mouse).Two alternatively spliced human isoforms have been described.
| Target |
BCAR3 |
| Reactivity |
Human |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Tested Applications |
WB |
| Recommended dilutions |
Optimal dilutions/concentrations should be determined by the end user. |
| Purification |
Purified by affinity chromatography. |
| Conjugation |
Unconjugated |
| Storage |
Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Swiss Prot |
O75815
|
| GeneID |
8412
|
| Gene Symbol |
BCAR3 |
| OMIM |
604704
|
| HGNC |
973 |
| Ensembl |
ENSG00000137936 |
| Buffer |
PBS, pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol. |
| UNSPSC Code |
12352203 |
| Availability |
Shipped within 5-10 working days. |
| Note |
This product is for research use only. |
