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產(chǎn)品名稱: BRCA1 (pS1457) Antibody
產(chǎn)品型號: abx012047
產(chǎn)品展商: 其他品牌
產(chǎn)品文檔: 無相關文檔
簡單介紹
BRCA1 (pS1457) Antibody
的詳細介紹
Phospho-BRCA1 (Ser1457) Antibody detects endogenous levels of BRCA1 only when phosphorylated at Sersine 1457. This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability and acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as BASC for BRCA1-associated genome surveillance complex. This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complex. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants have been described for this gene but only some have had their full-length natures identified.
| Target |
BRCA1 (pS1457) |
| Reactivity |
Human |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Tested Applications |
WB |
| Recommended dilutions |
Optimal dilutions/concentrations should be determined by the end user. |
| Purification |
Purified by affinity chromatography. |
| Conjugation |
Unconjugated |
| Storage |
Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Swiss Prot |
P38398
|
| GeneID |
672
|
| Gene Symbol |
BRCA1 |
| OMIM |
113705
|
| HGNC |
1100 |
| Ensembl |
ENSG00000012048 |
| Buffer |
PBS, pH 7.4, 150 mM NaCl, 0.02% sodium azide and 50% glycerol. |
| UNSPSC Code |
12352203 |
| Availability |
Shipped within 5-10 working days. |
| Note |
This product is for research use only. |
