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產(chǎn)品名稱: Bim BH3 Domain Antibody
產(chǎn)品型號(hào): abx027202
產(chǎn)品展商: 其他品牌
產(chǎn)品文檔: 無相關(guān)文檔
簡(jiǎn)單介紹
Bim BH3 Domain Antibody
的詳細(xì)介紹
Bim belongs to the BCL-2 protein family. BCL-2 family members form hetero or homodimers and act as anti or pro-apoptotic regulators that are involved in a wide variety of cellular activities. Bim contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X (L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection.
| Target |
Bim BH3 Domain |
| Reactivity |
Human |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Tested Applications |
WB, IHC |
| Recommended dilutions |
Optimal dilutions/concentrations should be determined by the end user. |
| Immunogen |
Human Bim BH3 Domain. |
| Purification |
Purified Rabbit Polyclonal Antibody. |
| Isotype |
IgG |
| Conjugation |
Unconjugated |
| Specificity |
This Bim BH3 Domain antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 130-165 amino acids from human Bim BH3 Domain. |
| Storage |
Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Swiss Prot |
O43521
|
| NCBI Accession |
NP_001191035.1
NP_001191036.1
NP_001191037.1
NP_001191038.1
NP_001191039.1
NP_001191040.1
NP_001191041.1
NP_001191042.1
NP_006529.1
NP_619527.1
NP_619528.1
NP_619529.1
NP_619530.1
NP_619531.1
NP_61953
|
| Buffer |
PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS. |
| UNSPSC Code |
12352203 |
| Availability |
Shipped within 5-10 working days. |
| Note |
This product is for research use only. |
