B-Lymphocyte Activation Antigen B7-1 (CD80) Antibody (APC)
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產(chǎn)品名稱: B-Lymphocyte Activation Antigen B7-1 (CD80) Antibody (APC)
產(chǎn)品型號: abx200458
產(chǎn)品展商: 其他品牌
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簡單介紹
B-Lymphocyte Activation Antigen B7-1 (CD80) Antibody (APC)
B-Lymphocyte Activation Antigen B7-1 (CD80) Antibody (APC)
的詳細(xì)介紹
CD80, also known as B7-1, B7, and BB1, is a 60 kD single chain type I glycoprotein belonging to the immunoglobulin superfamily. CD80 is expressed on activated B and T cells, macrophages, and dendritic cells. CD80 binds to CD28 and CD152 (CTLA-4). Along with CD86, CD80 plays a critical role in regulation of T cell activation.
| Target |
CD80 |
| Reactivity |
Human |
| Host |
Mouse |
| Clonality |
Monoclonal |
| Tested Applications |
FCM |
| Recommended dilutions |
FCM: 20 μl/1 million cells. Optimal dilutions/concentrations should be determined by the end user. |
| Immunogen |
Human CD80. |
| Purification |
Affinity Chromatography |
| Form |
Liquid |
| Isotype |
IgG1 |
| Conjugation |
APC |
| Specificity |
CD80 is involved in the costimulatory signal essential for T-lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation. The interaction of CD80 with CD28 provides a potent costimulatory signal for T cell activation through the CD3 complex, while its interaction with CTLA-4 provides an inhibitory signal for T cell activation. |
| Storage |
Store in the dark at 2-8 °C. |
| Molecular Weight |
60 kDa |
| Swiss Prot |
P33681
|
| GeneID |
941
|
| Buffer |
The reagent is provided in aqueous buffered solution containing protein stabilizer, and ≤0.09% sodium Azide |
| UNSPSC Code |
12352203 |
| Availability |
Shipped within 2-3 weeks. |
| Note |
This product is for research use only. |
