3-Hydroxyanthranilate 3,4-Dioxygenase (HAAO) Antibody
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產(chǎn)品名稱: 3-Hydroxyanthranilate 3,4-Dioxygenase (HAAO) Antibody
產(chǎn)品型號: abx003422
產(chǎn)品展商: 其他品牌
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簡單介紹
3-Hydroxyanthranilate 3,4-Dioxygenase (HAAO) Antibody
3-Hydroxyanthranilate 3,4-Dioxygenase (HAAO) Antibody
的詳細(xì)介紹
HAAO Antibody is a Rabbit Polyclonal antibody against HAAO. 3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN.
| Target |
HAAO |
| Reactivity |
Mouse, Rat |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Tested Applications |
WB |
| Recommended dilutions |
WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Immunogen |
Recombinant protein of human HAAO. |
| Purification |
Affinity purified. |
| Form |
Liquid |
| Isotype |
IgG |
| Conjugation |
Unconjugated |
| Storage |
Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Molecular Weight |
Calculated MW: 17 kDa/32 kDa
Observed MW: 38 kDa |
| Swiss Prot |
P46952
|
| GeneID |
23498
|
| Gene Symbol |
HAAO |
| Concentration |
> 1 mg/ml |
| Buffer |
PBS, pH 7.3, 0.02% sodium azide, 50% glycerol. |
| UNSPSC Code |
12352203 |
| Availability |
Shipped within 5-10 working days. |
| Note |
This product is for research use only. |
