3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) Antibody
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產(chǎn)品名稱: 3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) Antibody
產(chǎn)品型號: abx001376
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簡單介紹
3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) Antibody
3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) Antibody
的詳細介紹
HMGCR Antibody is a Rabbit Polyclonal antibody against HMGCR. HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008].
| Target |
HMGCR |
| Reactivity |
Human, Mouse, Rat |
| Host |
Rabbit |
| Clonality |
Polyclonal |
| Tested Applications |
WB |
| Recommended dilutions |
WB: 1/1000 - 1/4000. Optimal dilutions/concentrations should be determined by the end user. |
| Immunogen |
Recombinant protein of human HMGCR. |
| Purification |
Affinity purified. |
| Form |
Liquid |
| Isotype |
IgG |
| Conjugation |
Unconjugated |
| Storage |
Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Molecular Weight |
Calculated MW: 92 kDa/97 kDa/99 kDa
Observed MW: 110 kDa |
| Swiss Prot |
P04035
|
| GeneID |
3156
|
| Gene Symbol |
HMGCR |
| Concentration |
> 1 mg/ml |
| Buffer |
PBS, pH 7.3, 0.02% sodium azide, 50% glycerol. |
| UNSPSC Code |
12352203 |
| Availability |
Shipped within 5-10 working days. |
| Note |
This product is for research use only. |
