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產(chǎn)品名稱: Nanog Adenovirus (Human)
產(chǎn)品型號(hào):
產(chǎn)品展商: 其他品牌
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
Nanog Adenovirus (Human)
Nanog Adenovirus (Human)
的詳細(xì)介紹
|
Print Version |
| Vector |
pAdeno |
| Promoter |
CMV |
| Insert |
Nanog |
| Picture |
 |
| Organism |
Human |
| Accession # |
Q9H9S0 |
| Protein Type |
Wild Type |
| Protein Family |
Belongs to the Nanog homeobox family. |
| Functions |
Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. When overexpressed, promotes cells to enter into S phase and proliferation. The product can be used in combination with other iPSC factor for the induction of iPSC reprogramming. |
| Cell Types |
Expressed in fetal gonads, ovary and testis. |
| Protein Location |
Nucleus |
| Tag |
N-term His |
| Purification |
By Ion-Exchange column. |
| Quality Control |
By sequencing and Western blot analysis of transgene expression in transduced cells. Functional test includes iPSC reprogramming. |
| Titer |
>1x106pfu/mL |
| Storage |
10 mM Tris-HCl, pH 8.0 |
| Shipping |
High titer adenoviruses are shipped with dry ice and low titer adenoviruses are shipped with ice packs. For long term storage, it is recommended to store the viruses at -80°C in small aliquots to avoid repeated freeze-thaw cycles. |
| Notes |
There are 8 more vials in Box 24 Row E. |
