Product Name
Pyrin (MEFV), Recombinant Protein
Full Product Name
Recombinant Human Pyrin (MEFV), partial
Product Gene Name
MEFV recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
375-781aa; partial
Sequence
CKRHLKQVQL LFCEDHDEPI CLICSLSQEH QGHRVRPIEE VALEHKKKIQ KQLEHLKKLR KSGEEQRSYG EEKAVSFLKQ TEALKQRVQR KLEQVYYFLE QQEHFFVASL EDVGQMVGQI RKAYDTRVSQ DIALLDALIG ELEAKECQSE WELLQDIGDI LHRAKTVPVP EKWTTPQEIK QKIQLLHQKS EFVEKSTKYF SETLRSEMEM FNVPELIGAQ AHAVNVILDA ETAYPNLIFS DDLKSVRLGN KWERLPDGPQ RFDSCIIVLG SPSFLSGRRY WEVEVGDKTA WILGACKTSI SRKGNMTLSP ENGYWVVIMM KENEYQASSV PPTRLLIKEP PKRVGIFVDY RVGSISFYNV TARSHIYTFA SCSFSGPLQP IFSPGTRDGG KNTAPLTICP VGGQGPD
3D Structure
ModBase 3D Structure for O15553
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of MEFV recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for MEFV. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000234.1
[Other Products]
NCBI GenBank Nucleotide #
NM_000243.2
[Other Products]
UniProt Primary Accession #
O15553
[Other Products]
UniProt Related Accession #
O15553[Other Products]
NCBI Official Full Name
pyrin isoform 1
NCBI Official Synonym Full Names
MEFV, pyrin innate immunity regulator
NCBI Official Symbol
MEFV??[Similar Products]
NCBI Official Synonym Symbols
FMF; MEF; TRIM20
??[Similar Products]
NCBI Protein Information
pyrin
NCBI Summary for MEFV
This gene encodes a protein, also known as pyrin or marenostrin, that is an important modulator of innate immunity. Mutations in this gene are associated with Mediterranean fever, a hereditary periodic fever syndrome. [provided by RefSeq, Jul 2008]
Research Articles on MEFV
1. This article summarizes the broad spectrum of clinical presentations associated with MEFV mutations and analyzes the effect of the gene dose on the phenotypical expression. Furthermore, the impact of the molecular genetic analysis on the diagnostics of a patient and on the individualized management of the disease is discussed.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
