Product Name
APRIL, Recombinant Protein
Full Product Name
Mouse APRIL
Product Synonym Names
Recombinant Murine APRIL
Product Gene Name
APRIL recombinant protein
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
MRREVSRLQR SGGPSQKQGE RPWQSLWEQS PDVLEAWKDG AKSRRR RAVL TQKHKKKHSV LHLVPVNITS KDSDVTEVMW QPVLRRGRGL E AQGDIVRVW DTGIYLLYSQ VLFHDVTFTM GQVVSREGQG RRETLFR CIR SMPSDPDRAY NSCYSAGVFH LHQGDIITVK IPRANAKLSL SP HGTFLGFV KL
Chromosome Location
Chromosome: 11; NC_000077.6 (69682577..69685554, complement). Location: 11; 11 B4
3D Structure
ModBase 3D Structure for Q9D777
Purity/Purification
> 98% by SDS-PAGE and HPLC
Endotoxin Level
< 0.1 ng per ug of APRIL
Biological Activity
Measured by its ability to induce cell proliferation of activated T cells.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of APRIL recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
APRIL recombinant protein
APRIL (a proliferation inducing ligand), also known as TNFSF13, TALL2, and TRDL1, is a member of the TNF ligand superfamily. It is synthesized as a 32 kDa type II transmembrane protein which is cleaved by furin in the Golgi to release a 17 kDa soluble molecule. Secreted APRIL consists almost entirely of a single TNF homology domain. Little or no transmembrane APRIL is expressed on the cell surface. Alternate splicing generates isoforms with short deletions at the Nor C-terminus. Both APRIL and the closely related protein BAFF signal through the TNF superfamily receptors TACI and BCMA to promote cellular proliferation and protect from apoptosis. APRIL can form bioactive heterotrimers with BAFF. A bioactive cell surface-expressed protein known as TWEPRIL consists of the intracellular domain, transmembrane segment, and stalk region of TWEAK fused to the TNF homology domain of APRIL. Human APRIL shares 85% amino acid sequence identity with mouse and rat APRIL.
Product Categories/Family for APRIL recombinant protein
Cytokines & Growth Factors
NCBI/Uniprot data below describe general gene information for APRIL. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001152977.1
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NCBI GenBank Nucleotide #
NM_001159505.1
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UniProt Primary Accession #
Q9D777
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UniProt Secondary Accession #
Q9ERP1[Other Products]
UniProt Related Accession #
Q9D777[Other Products]
Molecular Weight
21.9 kDa
NCBI Official Full Name
tumor necrosis factor ligand superfamily member 13 isoform 2
NCBI Official Synonym Full Names
tumor necrosis factor (ligand) superfamily, member 13
NCBI Official Symbol
Tnfsf13??[Similar Products]
NCBI Official Synonym Symbols
April; Tall2; Trdl1; 2310026N09Rik
??[Similar Products]
NCBI Protein Information
tumor necrosis factor ligand superfamily member 13; a proliferation-inducing ligand
UniProt Protein Name
Tumor necrosis factor ligand superfamily member 13
UniProt Synonym Protein Names
A proliferation-inducing ligand
UniProt Gene Name
Tnfsf13??[Similar Products]
UniProt Synonym Gene Names
April; APRIL??[Similar Products]
UniProt Entry Name
TNF13_MOUSE
UniProt Comments for APRIL
Function: Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes. Ref.4
Subunit structure: Homotrimer
Potential.
Subcellular location: Secreted
By similarity.
Post-translational modification: The soluble form derives from the membrane form by proteolytic processing.
Miscellaneous: Transgenic mice develop lymphoid tumors that originate from expansion of the peritoneal B-1 B-cell population. Aging transgenic mice develop progressive hyperplasia in mesenteric lymph nodes and Peyer patches, disorganization of affected lymphoid tissues, mucosal and capsular infiltration, and eventual tumor cell infiltration into non-lymphoid tissues such as kidney and liver (Ref.4).
Sequence similarities: Belongs to the tumor necrosis factor family.
Research Articles on APRIL
1. Data indicate that APRIL expression accelerates the onset of TCL1-driven leukemia formation mainly through TACI activation.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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