AKU; HGO

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

The antibody detects endogenous levels of total HGD protein.

Antigen Affinity Purification

Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.

1 mg/ml (lot specific)

Store at -20 degree C

Small volumes of anti-HGD antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This gene encodes the enzyme homogentisate 1,2 dioxygenase. This enzyme is involved in the catabolism of the amino acids tyrosine and phenylalanine. Mutations in this gene are the cause of the autosomal recessive metabolism disorder alkaptonuria.

Total protein Ab

Western Blot (WB), Immunohistochemistry (IHC)

Western Blot: 1:500-1:2000
Immunohistochemistry: 1:10-1:50

Gel: 8%SDS-PAGE Lysate: 40 μ g Lane: Human normal liver tissue Primary antibody: 1/400 dilution Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution Exposure time: 3 seconds

Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue using at dilution 1/20.

Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using at dilution 1/20.

49,964 Da

homogentisate 1,2-dioxygenase

homogentisate 1,2-dioxygenase

Homogentisate 1,2-dioxygenase

HGO??[Similar Products]

HGD_HUMAN

HGD: Defects in HGD are the cause of alkaptonuria (AKU). AKU is an autosomal recessive error of metabolism characterized by an increase in the level of homogentisic acid. The clinical manifestations of AKU are urine that turns dark on standing and alkalinization, black ochronotic pigmentation of cartilage and collagenous tissues, and spine arthritis. Belongs to the homogentisate dioxygenase family.

Protein type: Amino Acid Metabolism - tyrosine; EC 1.13.11.5; Oxidoreductase

Chromosomal Location of Human Ortholog: 3q13.33

Cellular Component: cytosol

Molecular Function: homogentisate 1,2-dioxygenase activity; identical protein binding; protein binding

Biological Process: L-phenylalanine catabolic process

Disease: Alkaptonuria

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