Product Name
Alternate Syntide (FLI1), Peptide
Full Product Name
Alternate Syntide
Product Gene Name
FLI1 peptide
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
Pro-Leu-Se r-Arg-Thr- Leu-Ser-Va l-Ser-Ser- Leu-Pro-Gl y-Leu-NH2
Purity/Purification
> 95%
Form/Format
Lyophilized powder
Molecular Formula
C63H112N18O19
Preparation and Storage
Shipped at 4 degree C. Store at -20 degree C for one year.
Other Notes
Small volumes of FLI1 peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
FLI1 peptide
Peptide to Alternate Syntide
NCBI/Uniprot data below describe general gene information for FLI1. It may not necessarily be applicable to this product.
NCBI Accession #
AAA58479.1
[Other Products]
UniProt Secondary Accession #
Q14319; Q92480; Q9UE07; B2R8H2; B4DFV4; B4DTC6; G3V183[Other Products]
UniProt Related Accession #
Q01543[Other Products]
Molecular Weight
1425.7[Similar Products]
NCBI Official Full Name
alternate
NCBI Official Synonym Full Names
Fli-1 proto-oncogene, ETS transcription factor
NCBI Official Symbol
FLI1??[Similar Products]
NCBI Official Synonym Symbols
EWSR2; SIC-1
??[Similar Products]
NCBI Protein Information
Friend leukemia integration 1 transcription factor
UniProt Protein Name
Friend leukemia integration 1 transcription factor
UniProt Synonym Protein Names
Proto-oncogene Fli-1; Transcription factor ERGB
Protein Family
Retroviral integration site protein
UniProt Gene Name
FLI1??[Similar Products]
UniProt Entry Name
FLI1_HUMAN
NCBI Summary for FLI1
This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
UniProt Comments for FLI1
FLI1: Sequence-specific transcriptional activator. Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'. Defects in FLI1 are a cause of Ewing sarcoma (ES). A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. A chromosomal aberration involving FLI1 is found in patients with Erwing sarcoma. Translocation t(11;22)(q24;q12) with EWSR1. Belongs to the ETS family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 11q24.1-q24.3
Cellular Component: nucleus
Molecular Function: DNA binding; protein binding; transcription factor activity
Biological Process: cell differentiation; hemostasis; regulation of transcription from RNA polymerase II promoter
Research Articles on FLI1
1. erythrocyte lineage enforces exclusivity through upregulation of EKLF and its lineage-specific cytokine receptor (EpoR) while inhibiting both FLI-1 and the receptor TpoR (also known as MPL) for the opposing megakaryocyte lineage
Precautions
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Disclaimer
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