Human Stimulated by retinoic acid gene 6 protein homolog (STRA6) ELISA kit; FLJ12541; MCOPS9; PP14296; stimulated by retinoic acid gene 6 homolog; stimulated by retinoic acid gene 6 homolog (mouse)

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of STRA6 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9337870 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the stimulated by retinoic acid gene 6 homolog (mouse) (STRA6) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing STRA6. The ELISA analytical biochemical technique of the MBS9337870 kit is based on STRA6 antibody-STRA6 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect STRA6 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, STRA6. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

73,503 Da

stimulated by retinoic acid 6

stimulated by retinoic acid gene 6 protein homolog; retinol binding protein 4 receptor; stimulated by retinoic acid 6 homolog; stimulated by retinoic acid gene 6 homolog

Stimulated by retinoic acid gene 6 protein homolog

PP14296; UNQ3126/PRO10282/PRO19578??[Similar Products]

STRA6_HUMAN

The protein encoded by this gene is a membrane protein involved in the metabolism of retinol. The encoded protein acts as a receptor for retinol/retinol binding protein complexes. This protein removes the retinol from the complex and transports it across the cell membrane. Defects in this gene are a cause of syndromic microphthalmia type 9 (MCOPS9). Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

STRA6: May act as a high-affinity cell-surface receptor for the complex retinol-retinol binding protein (RBP/RBP4). Acts by removing retinol from RBP/RBP4 and transports it across the plasma membrane, where it can be metabolized. This mechanism does not depend on endocytosis. Binds to RBP/RBP4 with high affinity. Increases cellular retinol uptake from the retinol-RBP complex. Defects in STRA6 are the cause of microphthalmia syndromic type 9 (MCOPS9); also called Matthew-Wood syndrome or Spear syndrome. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS9 is a rare clinical entity including as main characteristics anophthalmia or severe microphthalmia, and pulmonary hypoplasia or aplasia. Mutations in STRA6 may be a cause of isolated colobomatous microphthalmia, a disorder of the eye characterized by an abnormally small ocular globe. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 15q24.1

Cellular Component: protein complex; integral to membrane; plasma membrane

Molecular Function: receptor activity; vitamin transporter activity

Biological Process: phototransduction, visible light; developmental growth; blood vessel development; adrenal gland development; heart development; neuromuscular process; ear development; positive regulation of JAK-STAT cascade; digestive tract morphogenesis; learning; vocal learning; female genitalia development; nose morphogenesis; smooth muscle development; positive regulation of behavior; artery morphogenesis; retinoic acid metabolic process; feeding behavior; retinoid metabolic process; cognition; kidney development; alveolus development; embryonic gut development; lung development

Disease: Microphthalmia, Syndromic 9

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