Full Product Name
ARP-1 Antibody
Product Synonym Names
NR2F2; ARP1; ARP-1; COUP transcription factor II; COUP-TF II; COUP-TF2; COUP-TFII; COUPTFB; COUPTFII; COUP transcription factor 2; EAR3; NF-E3; SVP40; COUPTF-II; TFCOUP2
Product Gene Name
anti-ARP-1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P24468
Specificity
ARP-1 Antibody detects endogenous levels of total ARP-1
Form/Format
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1.0mg/mL (lot specific)
Immunogen
A synthesized peptide derived from human ARP-1
Preparation and Storage
Store at -20 degree C
Other Notes
Small volumes of anti-ARP-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-ARP-1 antibody
Total protein Ab
Applications Tested/Suitable for anti-ARP-1 antibody
Western Blot (WB)
Application Notes for anti-ARP-1 antibody
Western Blot: 1:1000
Western Blot (WB) of anti-ARP-1 antibody
Western blot analysis ARP-1 using HuvEc whole cell lysates
NCBI/Uniprot data below describe general gene information for ARP-1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001138627.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001145155.1
[Other Products]
UniProt Primary Accession #
P24468
[Other Products]
UniProt Secondary Accession #
Q03754; Q3KQR7; B4DQJ2; B6ZGU1[Other Products]
UniProt Related Accession #
P24468[Other Products]
Molecular Weight
29,163 Da
NCBI Official Full Name
COUP transcription factor 2 isoform b
NCBI Official Synonym Full Names
nuclear receptor subfamily 2 group F member 2
NCBI Official Symbol
NR2F2??[Similar Products]
NCBI Official Synonym Symbols
ARP1; CHTD4; NF-E3; NR2F1; SVP40; COUPTFB; TFCOUP2; COUPTFII
??[Similar Products]
NCBI Protein Information
COUP transcription factor 2
UniProt Protein Name
COUP transcription factor 2
UniProt Synonym Protein Names
Apolipoprotein A-I regulatory protein 1; ARP-1; COUP transcription factor II; COUP-TF II; Nuclear receptor subfamily 2 group F member 2
UniProt Gene Name
NR2F2??[Similar Products]
UniProt Synonym Gene Names
ARP1; TFCOUP2; COUP-TF2; ARP-1; COUP-TF II??[Similar Products]
UniProt Entry Name
COT2_HUMAN
NCBI Summary for ARP-1
This gene encodes a member of the steroid thyroid hormone superfamily of nuclear receptors. The encoded protein is a ligand inducible transcription factor that is involved in the regulation of many different genes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
UniProt Comments for ARP-1
NR2F2: Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A. Interacts with SQSTM1. Binds DNA as a dimer; homodimer or heterodimer with NR2F6. Interacts with NCOA1, NCOA2, NCOA3 and PPARGC1A. Interacts with ZFPM2. Ubiquitous. Belongs to the nuclear hormone receptor family. NR2 subfamily. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor
Chromosomal Location of Human Ortholog: 15q26
Cellular Component: nucleus
Molecular Function: ligand-dependent nuclear receptor activity; protein binding; protein homodimerization activity; retinoic acid binding; sequence-specific DNA binding; transcription corepressor activity; transcription factor activity
Biological Process: lipid metabolic process; negative regulation of cyclin-dependent protein kinase activity; negative regulation of endothelial cell proliferation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; regulation of transcription from RNA polymerase II promoter; signal transduction
Disease: Congenital Heart Defects, Multiple Types, 4
Research Articles on ARP-1
1. Positive COUP-TF II expression levels has significant value in determining CRC stage and metastasis and cooperates with negative Smad4 expression contributing to assess prognosis in patients with colorectal cancer.
Precautions
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Disclaimer
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