Product Name
RPS6KA3, cDNA Clone
Full Product Name
RPS6KA3 cDNA Clone
Product Gene Name
RPS6KA3 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
ATGCCGCTGG CGCAGCTGGC GGACCCGTGG CAGAAGATGG CTGTGGAGAG CCCGTCCGAC AGCGCTGAGA ATGGACAGCA AATTATGGAT GAACCTATGG GAGAGGAGGA GATTAACCCA CAAACTGAAG AAGTCAGTAT CAAAGAAATT GCAATCACAC ATCATGTAAA GGAAGGACAT GAAAAGGCAG ATCCTTCCCA GTTTGAACTT TTAAAAGTAT TAGGGCAGGG ATCATTTGGA AAGGTTTTCT TAGTTAAAAA AATCTCAGGC TCTGATGCTA GGCAGCTTTA TGCCATGAAG GTATTGAAGA AGGCCACACT GAAAGTTCGA GACCGAGTTC GGACAAAAAT GGAACGTGAT ATCTTGGTAG AGGTTAATCA TCCTTTTATT GTCAAGTTGC ATTATGCTTT TCAAACTGAA GGGAAGTTGT ATCTTATTTT GGATTTTCTC AGGGGAGGAG ATTTGTTTAC ACGCTTATCC AAAGAGGTGA TGTTCACAGA AGAAGATGTC AAATTCTACT TGGCTGAACT TGCACTTGCT TTAGACCATC TACATAGCCT GGGAATAATT TATAGAGACT TAAAACCAGA AAATATACTT CTTGATGAAG AAGGTCACAT CAAGTTAACA GATTTCGGCC TAAGTAAAGA GTCTATTGAC CATGAAAAGA AGGCATATTC TTTTTGTGGA ACTGTGGAGT ATATGGCTCC AGAAGTAGTT AATCGTCGAG GTCATACTCA GAGTGCTGAC TGGTGGTCTT TTGGTGTGTT AATGTTTGAA ATGCTTACTG GTACACTCCC TTTCCAAGGA AAAGATCGAA AAGAAACAAT GACTATGATT CTTAAAGCCA AACTTGGAAT GCCACAGTTT TTGAGTCCTG AAGCGCAGAG TCTTTTACGA ATGCTTTTCA AGCGAAATCC TGCAAACAGA TTAGGTGCAG GACCAGATGG AGTTGAAGAA ATTAAAAGAC ATTCATTTTT CTCAACGATA GACTGGAATA AACTGTATAG AAGAGAAATT CATCCGCCAT TTAAACCTGC AACGGGCAGG CCTGAAGATA CATTCTATTT TGATCCTGAG TTTACTGCAA AAACTCCCAA AGATTCACCT GGCATTCCAC CTAGTGCTAA TGCACATCAG CTTTTTCGGG GGTTTAGTTT TGTTGCTATT ACCTCAGATG ATGAAAGCCA AGCTATGCAG ACAGTTGGTG TACATTCAAT TGTTCAGCAG TTACACAGGA ACAGTATTCA GTTTACTGAT GGATATGAAG TAAAAGAAGA TATTGGAGTT GGCTCCTACT CTGTTTGCAA GAGATGTATA CATAAAGCTA CAAACATGGA GTTTGCAGTG AAGATTATTG ATAAAAGCAA GAGAGACCCA ACAGAAGAAA TTGAAATTCT TCTTCGTTAT GGACAGCATC CAAACATTAT CACTCTAAAG GATGTATATG ATGATGGAAA GTATGTGTAT GTAGTAACAG AACTTATGAA AGGAGGTGAA TTGCTGGATA AAATTCTTAG ACAAAAATTT TTCTCTGAAC GAGAGGCCAG TGCTGTCCTG TTCACTATAA CTAAAACCGT TGAATATCTT CACGCACAAG GGGTGGTTCA TAGAGACTTG AAACCTAGCA ACATTCTTTA TGTGGATGAA TCTGGTAATC CGGAATCTAT TCGAATTTGT GATTTTGGCT TTGCAAAACA GCTGAGAGCG GAAAATGGTC TTCTCATGAC TCCTTGTTAC ACTGCAAATT TTGTTGCACC AGAGGTTTTA AAAAGACAAG GCTATGATGC TGCTTGTGAT ATATGGAGTC TTGGTGTCCT ACTCTATACA ATGCTTACCG GTTACACTCC ATTTGCAAAT GGTCCTGATG ATACACCAGA GGAAATATTG GCACGAATAG GTAGCGGAAA ATTCTCACTC AGTGGTGGTT ACTGGAATTC TGTTTCAGAC ACAGCAAAGG ACCTGGTGTC AAAGATGCTT CATGTAGACC CTCATCAGAG ACTGACTGCT GCTCTTGTGC TCAGACATCC TTGGATCGTC CACTGGGACC AACTGCCACA ATACCAACTA AACAGACAGG ATGCACCACA TCTAGTAAAG GGTGCCATGG CAGCTACATA TTCTGCTTTG AACCGTAATC AGTCACCAGT TTTGGAACCA GTAGGCCGCT CTACTCTTGC TCAGCGGAGA GGTATTAAAA AAATCACCTC AACAGCCCTG TGA
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of RPS6KA3 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for RPS6KA3. It may not necessarily be applicable to this product.
NCBI Accession #
BC096301
[Other Products]
UniProt Secondary Accession #
Q4VAP3; Q59H26; Q5JPK8; Q7Z3Z7; B2R9V4[Other Products]
UniProt Related Accession #
P51812[Other Products]
Molecular Weight
83,736 Da
NCBI Official Full Name
Homo sapiens ribosomal protein S6 kinase, 90kDa, polypeptide 3, mRNA
NCBI Official Synonym Full Names
ribosomal protein S6 kinase A3
NCBI Official Symbol
RPS6KA3??[Similar Products]
NCBI Official Synonym Symbols
CLS; RSK; HU-3; RSK2; MRX19; ISPK-1; p90-RSK2; pp90RSK2; MAPKAPK1B; S6K-alpha3
??[Similar Products]
NCBI Protein Information
ribosomal protein S6 kinase alpha-3
UniProt Protein Name
Ribosomal protein S6 kinase alpha-3
UniProt Synonym Protein Names
90 kDa ribosomal protein S6 kinase 3; p90-RSK 3; p90RSK3; Insulin-stimulated protein kinase 1; ISPK-1; MAP kinase-activated protein kinase 1b; MAPK-activated protein kinase 1b; MAPKAP kinase 1b; MAPKAPK-1b; Ribosomal S6 kinase 2; RSK-2; pp90RSK2
Protein Family
Ribosomal protein S6 kinase
UniProt Gene Name
RPS6KA3??[Similar Products]
UniProt Synonym Gene Names
ISPK1; MAPKAPK1B; RSK2; S6K-alpha-3; p90-RSK 3; p90RSK3; ISPK-1; MAPK-activated protein kinase 1b; MAPKAP kinase 1b; MAPKAPK-1b; RSK-2??[Similar Products]
UniProt Entry Name
KS6A3_HUMAN
NCBI Summary for RPS6KA3
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS). [provided by RefSeq, Jul 2008]
UniProt Comments for RPS6KA3
RSK2: an AGC kinase of the RSK family. Phosphorylated and activated by Erk1 and -2 in response to many growth factors, polypeptide hormones and neurotransmitters. Several phosphorylation sites are important for its activation. Possesses two kinase domains connected by a regulator linker region. Phosphorylates a wide range of substrates including ribosomal protein S6. Prominently expressed in brain structures essential for cognitive function and learning.
Protein type: Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Kinase, protein; Protein kinase, AGC; AGC group; RSK family; RSK subfamily
Chromosomal Location of Human Ortholog: Xp22.2-p22.1
Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function: caspase inhibitor activity; kinase activity; protein binding; protein kinase activity; protein serine/threonine kinase activity
Biological Process: central nervous system development; negative regulation of apoptosis; negative regulation of caspase activity; positive regulation of cell differentiation; positive regulation of cell growth; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription in response to stress; regulation of translation in response to stress; response to lipopolysaccharide; signal transduction; skeletal development; toll-like receptor signaling pathway
Disease: Coffin-lowry Syndrome; Mental Retardation, X-linked 19
Research Articles on RPS6KA3
1. Results indicate that the phosphorylation of EphA2 at Ser-897 is controlled by RSK and the RSK-EphA2 axis might contribute to cell motility and promote tumour malignant progression.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
