Product Name
14-3-3 sigma, Polyclonal Antibody
Full Product Name
14-3-3 sigma Polyclonal Antibody
Product Gene Name
anti-14-3-3 sigma antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P31947
Form/Format
Purified (Liquid)
Concentration
0.5mg/ml, 200μl (lot specific)
Immunogen
Full length recombinant 14-3-3 sigma protein was used as the immunogen for this antibody.
Preparation and Storage
Store antibody at 4 degree C, stable for 6 months. For long-term storage, store at -20 degree C. Avoid repeated freeze and thaw cycles. Expire 1 year from date of purchase.
Other Notes
Small volumes of anti-14-3-3 sigma antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-14-3-3 sigma antibody
Apoptosis
Applications Tested/Suitable for anti-14-3-3 sigma antibody
Western Blot (WB)
Application Notes for anti-14-3-3 sigma antibody
Western Blot: 1-3 μg/ml
Western Blot (WB) of anti-14-3-3 sigma antibody
Expression analysis of?14-3-3 sigma?.?Anti-?14-3-3 sigma?antibody (11-1020) was used at 1 and 2 μg/ml on Molt-4?lysate.
NCBI/Uniprot data below describe general gene information for 14-3-3 sigma. It may not necessarily be applicable to this product.
NCBI Accession #
NP_006133.1
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NCBI GenBank Nucleotide #
NM_006142.3
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UniProt Primary Accession #
P31947
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UniProt Secondary Accession #
Q6FH30; Q6FH51; Q96DH0[Other Products]
UniProt Related Accession #
P31947[Other Products]
Molecular Weight
24,336 Da
NCBI Official Full Name
14-3-3 protein sigma
NCBI Official Synonym Full Names
stratifin
NCBI Official Symbol
SFN??[Similar Products]
NCBI Official Synonym Symbols
YWHAS
??[Similar Products]
NCBI Protein Information
14-3-3 protein sigma; 14-3-3 sigma; epithelial cell marker protein 1
UniProt Protein Name
14-3-3 protein sigma
UniProt Synonym Protein Names
Epithelial cell marker protein 1; Stratifin
UniProt Gene Name
SFN??[Similar Products]
UniProt Synonym Gene Names
HME1??[Similar Products]
UniProt Entry Name
1433S_HUMAN
UniProt Comments for 14-3-3 sigma
14-3-3 sigma: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. Homodimer. Interacts with KRT17 and SAMSN1. Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. Interacts with GAB2. Interacts with SRPK2. Present mainly in tissues enriched in stratified squamous keratinizing epithelium. Belongs to the 14-3-3 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 1p36.11
Cellular Component: extracellular space; cytoplasmic vesicle membrane; cytoplasm; nucleus; cytosol
Molecular Function: protein domain specific binding; protein kinase C inhibitor activity; protein binding; phosphoprotein binding; protein kinase binding
Biological Process: positive regulation of protein export from nucleus; release of cytochrome c from mitochondria; regulation of epidermal cell division; DNA damage response, signal transduction resulting in induction of apoptosis; apoptosis; keratinization; positive regulation of epidermal cell differentiation; negative regulation of protein kinase activity; regulation of cyclin-dependent protein kinase activity; negative regulation of caspase activity; signal transduction; positive regulation of cell growth
Research Articles on 14-3-3 sigma
1. Results suggest a role of Wig-1 as a survival factor that directs the p53 stress response toward cell cycle arrest rather than apoptosis through the regulation of FAS and 14-3-3sigma mRNA levels.
Precautions
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Disclaimer
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