T-box transcription factor TBX4; T-box protein 4; TBX4

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit Ig

Rabbit

This TBX4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 103-129 amino acids from the N-terminal region of human TBX4.

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Vial Concentration: 0.35 (lot specific)

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-TBX4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This gene is a member of a phylogenetically conserved
family of genes that share a common DNA-binding domain, the T-box.
T-box genes encode transcription factors involved in the regulation
of developmental processes. This gene is the human homolog of mouse
Tbx4, which is closely linked to Tbx2 on mouse chromosome 11.
Similarly this gene, like TBX2, maps to human chromosome 17.
Expression studies in mouse and chicken show that Tbx4 is expressed
in developing hindlimb, but not in forelimb buds, suggesting a role
for this gene in regulating limb development and specification of
limb identity.

Crown Antibodies

Western Blot (WB), ELISA (EIA)

WB~~1:1000

TBX4 Antibody (N-term) western blot analysis in A549,mouse NIH/3T3 cell line lysates (35ug/lane).This demonstrates the TBX4 antibody detected the TBX4 protein (arrow).

60204

T-box 4

T-box transcription factor TBX4

T-box transcription factor TBX4

T-box protein 4??[Similar Products]

TBX4_HUMAN

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human homolog of mouse Tbx4, which is closely linked to Tbx2 on mouse chromosome 11. Similarly this gene, like TBX2, maps to human chromosome 17. Expression studies in mouse and chicken show that Tbx4 is expressed in developing hindlimb, but not in forelimb buds, suggesting a role for this gene in regulating limb development and specification of limb identity. [provided by RefSeq, Jul 2008]

TBX4: Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation. Defects in TBX4 are the cause of small patella syndrome (SPS); also known as ischiopatellar dysplasia or Scott-Taor syndrome. SPS is an autosomal dominant skeletal dysplasia characterized by patellar aplasia or hypoplasia and by anomalies of the pelvis and feet, including disrupted ossification of the ischia and inferior pubic rami.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 17q21-q22

Cellular Component: nucleus

Molecular Function: DNA binding; transcription factor activity

Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; skeletal morphogenesis; multicellular organismal development; morphogenesis of an epithelium; angiogenesis; limb morphogenesis; embryonic limb morphogenesis; lung development

Disease: Small Patella Syndrome

Kim, J.J., et al. J. Hum. Genet. 55(1):27-31(2010)
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Zhao, J., et al. BMC Med. Genet. 11, 96 (2010) :
Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)
Gudbjartsson, D.F., et al. Nat. Genet. 40(5):609-615(2008)

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