Product Name
acyl-CoA synthetase long-chain family member 5 (ACSL5), Polyclonal Antibody
Full Product Name
Rabbit anti-human acyl-CoA synthetase long-chain family member 5 polyclonal Antibody
Product Synonym Names
acyl-CoA synthetase long-chain family member 5; ACSL5; ACS2; ACS5; FACL5
Product Gene Name
anti-ACSL5 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen Affinity Purified
Storage Buffer
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20 degree C, Avoid freeze / thaw cycles.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-48002 / sc-47999 / sc-134508
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-ACSL5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-ACSL5 antibody
ELISA (EIA), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for ACSL5. It may not necessarily be applicable to this product.
NCBI Accession #
AAH07985.2
[Other Products]
UniProt Secondary Accession #
Q6UX44; Q9UIU4; A6GV77; D3DRB3[Other Products]
UniProt Related Accession #
Q9ULC5[Other Products]
Molecular Weight
73,278 Da[Similar Products]
NCBI Official Full Name
Acyl-CoA synthetase long-chain family member 5
NCBI Official Synonym Full Names
acyl-CoA synthetase long-chain family member 5
NCBI Official Symbol
ACSL5??[Similar Products]
NCBI Official Synonym Symbols
ACS2; ACS5; FACL5
??[Similar Products]
NCBI Protein Information
long-chain-fatty-acid--CoA ligase 5; LACS 5; fatty acid coenzyme A ligase 5; long-chain acyl-CoA synthetase 5; FACL5 for fatty acid coenzyme A ligase 5; long-chain fatty acid coenzyme A ligase 5; fatty-acid-Coenzyme A ligase, long-chain 5
UniProt Protein Name
Long-chain-fatty-acid--CoA ligase 5
UniProt Synonym Protein Names
Long-chain acyl-CoA synthetase 5; LACS 5
Protein Family
Long-chain-fatty-acid--CoA ligase
UniProt Gene Name
ACSL5??[Similar Products]
UniProt Synonym Gene Names
ACS5; FACL5; LACS 5??[Similar Products]
UniProt Entry Name
ACSL5_HUMAN
NCBI Summary for ACSL5
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for ACSL5
ACSL5: Acyl-CoA synthetases (ACSL) activate long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage. Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids. It was suggested that it may also stimulate fatty acid oxidation. At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of glioma cells. Belongs to the ATP-dependent AMP-binding enzyme family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Ligase; Mitochondrial; Lipid Metabolism - fatty acid; Membrane protein, integral; EC 6.2.1.3
Chromosomal Location of Human Ortholog: 10q25.2
Cellular Component: endoplasmic reticulum membrane; mitochondrial outer membrane; mitochondrion; membrane; endoplasmic reticulum; mitochondrial inner membrane; nucleolus; integral to membrane; nucleus
Molecular Function: ATP binding; long-chain-fatty-acid-CoA ligase activity
Biological Process: triacylglycerol biosynthetic process; cellular lipid metabolic process; long-chain fatty acid metabolic process
Research Articles on ACSL5
1. Down-regulation of ACSL5 is associated with colorectal cancer.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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