For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

This antibody recognizes human and rat GLUT2..

100ug (1mg/ml) peptide affinity-purified antibody in PBS, pH 7.4, 50% glycerol, 0.09% sodium azide.

Small volumes of anti-GLUT2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

GLUT2 is a member of the human glucose transport protein family. It is present in high concentration in the plasma membrane of pancreatic b-cells where it initiates the first step in glucose-stimulated insulin secretion. GLUT2 is required for glucose sensitivity in the hypothalamus and brain stem and is involved in control of food intake and stimulation of glucose uptake by peripheral tissues.

Immunoblot, Immunofluorescence (IF)

Immunoblot: 1:1,000; A bands of 57~kDa is detected. Bands of ~72kDa and ~37kDa may also be detected.
IF: 1:100

Detection of GLUT2 in rat liver lysate diluted 1:1,000.

Detection of GLUT2 in HeLa cell lysate (left) and human 293T cell lysate (right) diluted 1:1,000.

Detection of GLUT2 in human Colon cancer cell line (HT-29) diluted 1:100. DAPI (blue) nuclear stain, Texas red actin stain, and FITC (green) BDNF stain.

44,702 Da

solute carrier family 2 member 2

solute carrier family 2, facilitated glucose transporter member 2

Solute carrier family 2, facilitated glucose transporter member 2

GLUT2; GLUT-2??[Similar Products]

This gene encodes an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. The encoded protein mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. Mutations in this gene are associated with susceptibility to diseases, including Fanconi-Bickel syndrome and noninsulin-dependent diabetes mellitus (NIDDM). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na+/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney.

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