Product Name
CPN1, cDNA Clone
Full Product Name
CPN1 cDNA Clone
Product Gene Name
CPN1 cdna clone
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
atgtcagacc tgctctcagt cttcctccac ctcctccttc tcttcaagtt ggttgccccg gtgacctttc gccaccaccg ctatgatgat cttgtgcgga cgctgtacaa ggtgcaaaac gaatgccccg gcatcacgcg ggtctacagc attgggcgca gcgtggaggg gagacacctc tacgtgctgg agttcagcga ccaccctgga atccacgagc ccttggaacc agaggtcaag tatgtgggga acatgcacgg caacgaagcg ttgggccgcg agctgatgct gcagctgtcg gagtttctgt gcgaggagtt ccggaacagg aaccagcgca tcgtccagct catccaggac acgcgcattc acatcctgcc atccatgaac cccgacggct acgaggtggc tgctgcccag ggcccaaaca agcctgggta tctagttggc aggaacaatg caaatggagt ggacctgaac cgcaacttcc ctgatctcaa tacctatatc tactataacg agaagtacgg aggccccaac caccacctgc cccttccaga caactggaaa agtcaggtgg aacccgagac ccgggcggtg atccggtgga tgcactcctt caactttgtt ctttcagcca atctccacgg aggggcggtg gtggccaatt acccgtatga caagtccttt gagcaccggg tccgaggggt ccgccgcacc gccagcaccc ccacgcctga cgacaagctc ttccagaagc tggccaaggt ctactcctat gcacatggat ggatgttcca aggttggaac tgcggagatt acttcccaga tggcatcacc aatggagctt cctggtattc tctcagcaag ggaatgcaag actttaatta tctccatacc aactgctttg agatcacgct ggaactgagt tgcgacaagt ttccccccga agaggagtta cagcgggagt ggctgggtaa tcgggaagcc ctaatccagt tcctggaaca ggttcaccag ggcatcaagg gaatggtgct tgatgagaat tacaataatc tcgccaatgc tgtcatttct gtcagtggga ttaaccatga tgtcacttca ggtgaccatg gtgattactt ccggctgctg cttccaggta tctacactgt tagtgccaca gcacctgggt atgacccaga gacagtaact gtgaccgtgg gtcctgcgga accaacgttg gttaacttcc acctcaaaag aagcatccct caagtaagcc ctgtgaggag agctcccagc agaaggcacg gagtcagagc caaagtgcag ccccaagcca gaaagaaaga aatggagatg aggcagctgc agagaggccc tgcctga
Clone Sequence Report
Provided with product shipment
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of CPN1 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for CPN1. It may not necessarily be applicable to this product.
NCBI Accession #
BC027897
[Other Products]
UniProt Secondary Accession #
B1AP59[Other Products]
UniProt Related Accession #
P15169[Other Products]
Molecular Weight
52,286 Da
NCBI Official Full Name
Homo sapiens carboxypeptidase N, polypeptide 1, mRNA
NCBI Official Synonym Full Names
carboxypeptidase N subunit 1
NCBI Official Symbol
CPN1??[Similar Products]
NCBI Official Synonym Symbols
CPN; SCPN
??[Similar Products]
NCBI Protein Information
carboxypeptidase N catalytic chain
UniProt Protein Name
Carboxypeptidase N catalytic chain
UniProt Synonym Protein Names
Anaphylatoxin inactivator; Arginine carboxypeptidase; Carboxypeptidase N polypeptide 1; Carboxypeptidase N small subunit; Kininase-1; Lysine carboxypeptidase; Plasma carboxypeptidase B; Serum carboxypeptidase N; SCPN
Protein Family
Carboxypeptidase
UniProt Gene Name
CPN1??[Similar Products]
UniProt Synonym Gene Names
ACBP; CPN; SCPN??[Similar Products]
UniProt Entry Name
CBPN_HUMAN
NCBI Summary for CPN1
Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency. [provided by RefSeq, Jul 2008]
UniProt Comments for CPN1
CPN1: Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation. Defects in CPN1 are the cause of carboxypeptidase N deficiency (CPND). Patients affected present some combination of angioedema or chronic urticaria, as well as hay fever or astma, and have also slightly depressed serum carboxy peptidase N, suggestive of autosomal recessive inheritance of this disorder. Belongs to the peptidase M14 family.
Protein type: EC 3.4.17.3; Secreted, signal peptide; Protease; Secreted
Chromosomal Location of Human Ortholog: 10q24.2
Molecular Function: serine carboxypeptidase activity
Biological Process: peptide metabolic process; protein processing
Disease: Carboxypeptidase N Deficiency
Research Articles on CPN1
1. CPN binds to fibrinogen and is present in a fibrin clot prepared from plasma.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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