Product Name
LIFR, Recombinant Protein
Full Product Name
LIFR, 45-833aa, Human, His tag, Baculovirus
Product Synonym Names
Leukemia inhibitory factor receptor; LIFR; CD118; LIF-R; SJS2; STWS; SWS
Product Gene Name
LIFR recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
ADPQKKGAPH DLKCVTNNLQ VWNCSWKAPS GTGRGTDYEV CIENRSRSCY QLEKTSIKIP ALSHGDYEIT INSLHDFGSS TSKFTLNEQN VSLIPDTPEI LNLSADFSTS TLYLKWNDRG SVFPHRSNVI WEIKVLRKES MELVKLVTHN TTLNGKDTLH HWSWASDMPL ECAIHFVEIR CYIDNLHFSG LEEWSDWSPV KNISWIPDSQ TKVFPQDKVI LVGSDITFCC VSQEKVLSAL IGHTNCPLIH LDGENVAIKI RNISVSASSG TNVVFTTEDN IFGTVIFAGY PPDTPQQLNC ETHDLKEIIC SWNPGRVTAL VGPRATSYTL VESFSGKYVR LKRAEAPTNE SYQLLFQMLP NQEIYNFTLN AHNPLGRSQS TILVNITEKV YPHTPTSFKV KDINSTAVKL SWHLPGNFAK INFLCEIEIK KSNSVQEQRN VTIKGVENSS YLVALDKLNP YTLYTFRIRC STETFWKWSK WSNKKQHLTT EASPSKGPDT WREWSSDGKN LIIYWKPLPI NEANGKILSY NVSCSSDEET QSLSEIPDPQ HKAEIRLDKN DYIISVVAKN SVGSSPPSKI ASMEIPNDDL KIEQVVGMGK GILLTWHYDP NMTCDYVIKW CNSSRSEPCL MDWRKVPSNS TETVIESDEF RPGIRYNFFL YGCRNQGYQL LRSMIGYIEE LAPIVAPNFT VEDTSADSIL VKWEDIPVEE LRGFLRGYLF YFGKGERDTS KMRVLESGRS DIKVKNITDI SQKTLRIADL QGKTSYHLVL RAYTDGGVGP EKSMYVVTKE NSHHHHHH
3D Structure
ModBase 3D Structure for P42702
Purity/Purification
> 90% by SDS-PAGE
Form/Format
Liquid. In phosphate buffered saline (pH 7.4) containing 10% glycerol.
Concentration
0.5 mg/ml (determined by Absorbance at 280nm) (lot specific)
Endotoxin Level
< 1.0 EU per 1 microgram of protein (determined by LAL method)
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Other Notes
Small volumes of LIFR recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
LIFR recombinant protein
LIFR, also known as leukemia inhibitory factor receptor, is the receptor for leukemia inhibitory factor, a pleiotropic cytokine affecting the differentiation, survival, and proliferation of a wide variety of cells in the ***** and the embryo. LIFR plays an important role in several aspects of early pregnancy such as blastocyst implantation in the uterus. Recombinant human LIFR, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.
Product Categories/Family for LIFR recombinant protein
Immunology
Applications Tested/Suitable for LIFR recombinant protein
SDS-PAGE
SDS-Page of LIFR recombinant protein
NCBI/Uniprot data below describe general gene information for LIFR. It may not necessarily be applicable to this product.
NCBI Accession #
NP_002301
[Other Products]
NCBI GenBank Nucleotide #
NM_002310.5
[Other Products]
UniProt Primary Accession #
P42702
[Other Products]
UniProt Secondary Accession #
Q6LCD9[Other Products]
UniProt Related Accession #
P42702[Other Products]
Molecular Weight
90.5kDa (798aa) 100-150KDa (SDS-PAGE under reducing conditions.)
NCBI Official Full Name
leukemia inhibitory factor receptor
NCBI Official Synonym Full Names
LIF receptor alpha
NCBI Official Symbol
LIFR??[Similar Products]
NCBI Official Synonym Symbols
SWS; SJS2; STWS; CD118; LIF-R
??[Similar Products]
NCBI Protein Information
leukemia inhibitory factor receptor
UniProt Protein Name
Leukemia inhibitory factor receptor
UniProt Synonym Protein Names
CD_antigen: CD118
Protein Family
Leukemia inhibitory factor receptor
UniProt Gene Name
LIFR??[Similar Products]
UniProt Synonym Gene Names
LIF receptor; LIF-R??[Similar Products]
NCBI Summary for LIFR
This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the ***** and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, t(5;8)(p13;q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for LIFR
Signal-transducing molecule. May have a common pathway with IL6ST. The soluble form inhibits the
biological activity of LIF by blocking its binding to receptors on target cells.
Product References and Citations for LIFR recombinant protein
Gearing DP., et al. (1991) EMBO J. 10:2839-2848.; Cheng JG., et al. (2001) Proc Nati Acad Sci USA 98:8680-8685.
Research Articles on LIFR
1. Expression of cancer-specific glycan epitopes represents an excellent opportunity for diagnostics and potentially specific detection of tumors. Here, we report four proteins (LIFR, CE350, VP13A, HPT) found in sera from pancreatic cancer patients carrying aberrant glycan structures as compared to those of controls.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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