Full Product Name
CPN1 Rabbit Polyclonal
Product Gene Name
anti-CPN1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Immunogen
Carboxypeptidase N, polypeptide 1
Preparation and Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-CPN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CPN1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS), Immunofluorescence (IF)
NCBI/Uniprot data below describe general gene information for CPN1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001299.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001308.2
[Other Products]
UniProt Secondary Accession #
B1AP59[Other Products]
UniProt Related Accession #
P15169[Other Products]
Molecular Weight
52,286 Da
NCBI Official Full Name
carboxypeptidase N catalytic chain
NCBI Official Synonym Full Names
carboxypeptidase N subunit 1
NCBI Official Symbol
CPN1??[Similar Products]
NCBI Official Synonym Symbols
CPN; SCPN
??[Similar Products]
NCBI Protein Information
carboxypeptidase N catalytic chain
UniProt Protein Name
Carboxypeptidase N catalytic chain
UniProt Synonym Protein Names
Anaphylatoxin inactivator; Arginine carboxypeptidase; Carboxypeptidase N polypeptide 1; Carboxypeptidase N small subunit; Kininase-1; Lysine carboxypeptidase; Plasma carboxypeptidase B; Serum carboxypeptidase N; SCPN
Protein Family
Carboxypeptidase
UniProt Gene Name
CPN1??[Similar Products]
UniProt Synonym Gene Names
ACBP; CPN; SCPN??[Similar Products]
UniProt Entry Name
CBPN_HUMAN
NCBI Summary for CPN1
Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency. [provided by RefSeq, Jul 2008]
UniProt Comments for CPN1
CPN1: Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation. Defects in CPN1 are the cause of carboxypeptidase N deficiency (CPND). Patients affected present some combination of angioedema or chronic urticaria, as well as hay fever or astma, and have also slightly depressed serum carboxy peptidase N, suggestive of autosomal recessive inheritance of this disorder. Belongs to the peptidase M14 family.
Protein type: EC 3.4.17.3; Protease; Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 10q24.2
Cellular Component: extracellular space
Molecular Function: metallocarboxypeptidase activity; serine carboxypeptidase activity; zinc ion binding
Biological Process: peptide metabolic process; protein processing; response to glucocorticoid stimulus
Disease: Carboxypeptidase N Deficiency
Research Articles on CPN1
1. CPN binds to fibrinogen and is present in a fibrin clot prepared from plasma.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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