For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C.

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Small volumes of Cpn-Ab elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS2606716 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Cpn-Ab, ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing Cpn-Ab. The ELISA analytical biochemical technique of the MBS2606716 kit is based on Cpn-Ab antibody-Cpn-Ab antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect Cpn-Ab antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, Cpn-Ab. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

52,286 Da

carboxypeptidase N subunit 1

carboxypeptidase N catalytic chain

Carboxypeptidase N catalytic chain

ACBP; CPN; SCPN??[Similar Products]

CBPN_HUMAN

Carboxypeptidase N is a plasma metallo-protease that cleaves basic amino acids from the C terminal of peptides and proteins. The enzyme is important in the regulation of peptides like kinins and anaphylatoxins, and has also been known as kininase-1 and anaphylatoxin inactivator. This enzyme is a tetramer comprised of two identical regulatory subunits and two identical catalytic subunits; this gene encodes the catalytic subunit. Mutations in this gene can be associated with angioedema or chronic urticaria resulting from carboxypeptidase N deficiency. [provided by RefSeq, Jul 2008]

CPN1: Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation. Defects in CPN1 are the cause of carboxypeptidase N deficiency (CPND). Patients affected present some combination of angioedema or chronic urticaria, as well as hay fever or astma, and have also slightly depressed serum carboxy peptidase N, suggestive of autosomal recessive inheritance of this disorder. Belongs to the peptidase M14 family.

Protein type: Protease; EC 3.4.17.3; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 10q24.2

Cellular Component: extracellular space

Molecular Function: metallocarboxypeptidase activity; serine carboxypeptidase activity; zinc ion binding

Biological Process: peptide metabolic process; protein processing; response to glucocorticoid stimulus

Disease: Carboxypeptidase N Deficiency

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