Full Product Name
EMG1 Antibody
Product Gene Name
anti-EMG1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q92979
Other Notes
Small volumes of anti-EMG1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for EMG1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_006322.4
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NCBI GenBank Nucleotide #
NM_006331.7
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UniProt Primary Accession #
Q92979
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UniProt Secondary Accession #
O00675; O00726[Other Products]
UniProt Related Accession #
Q92979[Other Products]
Molecular Weight
26,720 Da
NCBI Official Full Name
ribosomal RNA small subunit methyltransferase NEP1 isoform 1
NCBI Official Synonym Full Names
EMG1, N1-specific pseudouridine methyltransferase
NCBI Official Symbol
EMG1??[Similar Products]
NCBI Official Synonym Symbols
C2F; NEP1; Grcc2f
??[Similar Products]
NCBI Protein Information
ribosomal RNA small subunit methyltransferase NEP1
UniProt Protein Name
Ribosomal RNA small subunit methyltransferase NEP1
UniProt Synonym Protein Names
18S rRNA (pseudouridine(1248)-N1)-methyltransferase
UniProt Gene Name
EMG1??[Similar Products]
NCBI Summary for EMG1
This gene encodes an essential, conserved eukaryotic protein that methylates pseudouridine in 18S rRNA. The related protein in yeast is a component of the small subunit processome and is essential for biogenesis of the ribosomal 40S subunit. A mutation in this gene has been associated with Bowen-Conradi syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
UniProt Comments for EMG1
S-adenosyl-L-methionine-dependent pseudouridine N1-methyltransferase that methylates pseudouridine at position 1248 (Psi1248) in 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Is not able to methylate uridine at this position (PubMed:20047967). Has also an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre-ribosomes ().
Research Articles on EMG1
1. Our findings further indicate that in Bowen-Conradi syndrome, nuclear disassembly of the import complex and release of EMG1D86G lead to its nuclear aggregation and degradation, resulting in the reduced nucleolar recruitment of the RNA methyltransferase and defects in the biogenesis of the small ribosomal subunit.
Precautions
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