Product Name
Neuropeptide W-23 (NPW), Polyclonal Antibody
Full Product Name
Neuropeptide W-23 (NPW23, L8)
Product Synonym Names
Anti -Neuropeptide W-23 (NPW23, L8)
Product Gene Name
anti-NPW antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 16; NC_000016.9 (2069521..2070756). Location: 16p13.3
3D Structure
ModBase 3D Structure for Q8N729
Species Reactivity
Mouse, Rat
Specificity
Recognizes human Neuropeptide W-23.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Form/Format
Supplied as a lyophilized powder. Reconstitute with sterile dH2O.
Immunogen
Synthetic peptide corresponding to rat Neuropeptide W-23.
Preparation and Storage
Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of anti-NPW antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-NPW antibody
Antibodies; Abs to Neuroscience
Application Notes for anti-NPW antibody
Suitable for use in ELISA.
NCBI/Uniprot data below describe general gene information for NPW. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001092926.2
[Other Products]
NCBI GenBank Nucleotide #
NM_001099456.2
[Other Products]
UniProt Primary Accession #
Q8N729
[Other Products]
UniProt Related Accession #
Q8N729[Other Products]
Molecular Weight
18,048 Da[Similar Products]
NCBI Official Full Name
neuropeptide W preproprotein
NCBI Official Synonym Full Names
neuropeptide W
NCBI Official Symbol
NPW??[Similar Products]
NCBI Official Synonym Symbols
L8; L8C; PPL8; PPNPW
??[Similar Products]
NCBI Protein Information
neuropeptide W; hPPL8; preproprotein L8; prepro-neuropeptide W
UniProt Protein Name
Neuropeptide W
UniProt Synonym Protein Names
Preproprotein L8
Protein Family
Neuropeptide
UniProt Gene Name
NPW??[Similar Products]
UniProt Synonym Gene Names
PPL8; PPNPW; hPPL8; NPW23; hL8; NPW30; hL8C??[Similar Products]
UniProt Entry Name
NPW_HUMAN
NCBI Summary for NPW
The product of this gene is processed into 23- and 30-amino acid neuropeptides that bind and activate two G-protein coupled receptors in the central nervous system. The neuropeptides have been shown to enhance cortisol secretion from adrenal cells through the adenylate cyclase/protein kinase A signaling cascade. The preproprotein is translated using a non-AUG initiation codon that is inferred from analyses of the mouse ortholog. [provided by RefSeq, Jul 2008]
UniProt Comments for NPW
NPW: Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress. NPW23 activates GPR7 and GPR8 more efficiently than NPW30. Belongs to the neuropeptide B/W family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component: extracellular region
Molecular Function: protein binding; G-protein-coupled receptor binding
Biological Process: G-protein coupled receptor protein signaling pathway; neuropeptide signaling pathway; feeding behavior
Research Articles on NPW
1. This review of NPW suggests that study of effects of this peptide may reveal its role in regulating feeding and energy metabolism coupled to leptin levels in the brain.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
