Product Name
Neuropeptide W (NPW), Recombinant Protein
Full Product Name
Recombinant Human Neuropeptide W (NPW), partial
Product Gene Name
NPW recombinant protein
[Similar Products]
Product Synonym Gene Name
NPW[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
33-62aa, Cytoplasmic domain
Sequence
WYKHVASPRY HTVGRAAGLL MGLRRSPYLW
3D Structure
ModBase 3D Structure for Q8N729
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of NPW recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
NPW recombinant protein
The product of this gene is processed into 23- and 30-amino acid neuropeptides that bind and activate two G-protein coupled receptors in the central nervous system. The neuropeptides have been shown to enhance cortisol secretion from adrenal cells through the adenylate cyclase
protein kinase A signaling cascade. The preproprotein is translated using a non-AUG initiation codon that is inferred from analyses of the mouse ortholog.
NCBI/Uniprot data below describe general gene information for NPW. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001092926.2
[Other Products]
NCBI GenBank Nucleotide #
NM_001099456.2
[Other Products]
UniProt Primary Accession #
Q8N729
[Other Products]
UniProt Related Accession #
Q8N729[Other Products]
Molecular Weight
18,048 Da
NCBI Official Full Name
neuropeptide W preproprotein
NCBI Official Synonym Full Names
neuropeptide W
NCBI Official Symbol
NPW??[Similar Products]
NCBI Official Synonym Symbols
L8; L8C; PPL8; PPNPW
??[Similar Products]
NCBI Protein Information
neuropeptide W
UniProt Protein Name
Neuropeptide W
UniProt Synonym Protein Names
Preproprotein L8; hPPL8
Protein Family
Neuropeptide
UniProt Gene Name
NPW??[Similar Products]
UniProt Synonym Gene Names
PPL8; PPNPW; hPPL8; NPW23; hL8; NPW30; hL8C??[Similar Products]
NCBI Summary for NPW
The product of this gene is processed into 23- and 30-amino acid neuropeptides that bind and activate two G-protein coupled receptors in the central nervous system. The neuropeptides have been shown to enhance cortisol secretion from adrenal cells through the adenylate cyclase/protein kinase A signaling cascade. The preproprotein is translated using a non-AUG initiation codon that is inferred from analyses of the mouse ortholog. [provided by RefSeq, Jul 2008]
UniProt Comments for NPW
Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress (). NPW23 activates GPR7 and GPR8 more efficiently than NPW30.
Research Articles on NPW
1. our data highlight that NPW modulates the CaV1.2 currents via G protein-coupled receptor 7, and the presence of it influences arterial tone.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.