Product Name
TAX1BP1, Polyclonal Antibody
Full Product Name
TAX1BP1 Antibody
Product Synonym Names
Tax1-binding protein 1; TRAF6-binding protein; TAX1BP1; T6BP; PRO0105
Product Gene Name
anti-TAX1BP1 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q86VP1
Species Reactivity
Human, Rat
Purity/Purification
>95%, Protein G purified
Immunogen
Recombinant Human Tax1-binding protein 1 protein (592-713AA)
Conjugation
Non-conjugated
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Preparation and Storage
Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-TAX1BP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TAX1BP1 antibody
Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade.
Product Categories/Family for anti-TAX1BP1 antibody
Signal transduction
Applications Tested/Suitable for anti-TAX1BP1 antibody
ELISA (EIA), Western Blot (WB)
Application Notes for anti-TAX1BP1 antibody
WB: 1:500-1:5000
Western Blot (WB) of anti-TAX1BP1 antibody
Western Blot
Positive WB detected in: Jurkat whole cell lysate
All lanes: TAX1BP1 antibody at 5.5ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 91, 87, 66, 69 KDa
Observed band size: 91, 69 KDa
NCBI/Uniprot data below describe general gene information for TAX1BP1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001073333.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001079864.2
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UniProt Primary Accession #
Q86VP1
[Other Products]
UniProt Secondary Accession #
O60398; O95770; Q13311; Q9BQG5; Q9UI88; A4D196; B4DKU7; E7ENV2[Other Products]
UniProt Related Accession #
Q86VP1[Other Products]
Molecular Weight
68,277 Da
NCBI Official Full Name
tax1-binding protein 1 isoform 2
NCBI Official Synonym Full Names
Tax1 binding protein 1
NCBI Official Symbol
TAX1BP1??[Similar Products]
NCBI Official Synonym Symbols
T6BP; TXBP151; CALCOCO3
??[Similar Products]
NCBI Protein Information
tax1-binding protein 1
UniProt Protein Name
Tax1-binding protein 1
UniProt Synonym Protein Names
TRAF6-binding protein
Protein Family
Tax1-binding protein
UniProt Gene Name
TAX1BP1??[Similar Products]
UniProt Synonym Gene Names
T6BP??[Similar Products]
NCBI Summary for TAX1BP1
This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]
UniProt Comments for TAX1BP1
Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade.
Research Articles on TAX1BP1
1. Results show that TAX1BP1 translocates to mitochondria in response to RNA virus infection and inducibly interacts with the MAVS adaptor protein and indicate that TAX1BP1 functions as an adaptor molecule for Itch to target MAVS during RNA virus infection and thus restrict virus-induced apoptosis.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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