Product Name
Sorting nexin-15 (Snx15), Recombinant Protein
Full Product Name
Recombinant Mouse Sorting nexin-15 (Snx15)
Product Gene Name
Snx15 recombinant protein
[Similar Products]
Product Synonym Gene Name
Snx15[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-337aa, full length protein
Sequence
MSRQAKDDFL RHYTVSDPRT HPKGYTEYKV TAQFISKKDP EDIKEVVVWK RYSDFRKLHG DLAYTHRNLF RRLEEFPAFP RAQVFGRFEA SVIEERRKGA EDLLRFTVPI PALNNSPQLK EFFRGGEVTR PSEVSRDLRI LPPPLIPTPP PDEARLLQPL PAERRGQEEL EVPVDPLPSS PAQEALDLLF SCDSTEEASS SLARGPLSEA ELALFDPYSK EESTGPSPTH TGELAAIEVE SKRLDQEPWE PGGQEEEEAE DGEPAPAYLG QATELITQAL RNEKAGAYAA ALQGYQDGVH ILLQGVSGDP SPARREGVKK KAAEYLKRAE MLHTHLP
3D Structure
ModBase 3D Structure for Q91WE1
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Snx15 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Snx15 recombinant protein
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. This gene encodes two transcript variants encoding distinct isoforms.
NCBI/Uniprot data below describe general gene information for Snx15. It may not necessarily be applicable to this product.
NCBI Accession #
NP_081188.1
[Other Products]
NCBI GenBank Nucleotide #
NM_026912.1
[Other Products]
UniProt Primary Accession #
Q91WE1
[Other Products]
UniProt Related Accession #
Q91WE1[Other Products]
Molecular Weight
37,742 Da
NCBI Official Full Name
sorting nexin-15
NCBI Official Synonym Full Names
sorting nexin 15
NCBI Official Symbol
Snx15??[Similar Products]
NCBI Official Synonym Symbols
1500032B08Rik; E130013C21Rik
??[Similar Products]
NCBI Protein Information
sorting nexin-15
UniProt Protein Name
Sorting nexin-15
Protein Family
Sorting nexin
UniProt Gene Name
Snx15??[Similar Products]
UniProt Comments for Snx15
May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN ().
Research Articles on Snx15
1. SNX15 regulates the recycling of APP to cell surface and, thus, its processing for Abeta generation.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
