Anti-AQP1 / Aquaporin 1 Antibody IHC-plus; AQP1; Aquaporin-1; AQP-1; AQP-CHIP; Aquaporin 1; Aquaporin-CHIP; CHIP28; Colton blood group; Urine water channel; CO; AQP1; Aquaporin 1

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

Detects ~28.5kDa.Glycosylated bands ~35-50kDa.

Affinity Purified

PBS pH7.4, 50% glycerol and 0.09% sodium azide

1 mg/ml (lot specific)

Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.

Small volumes of anti-AQP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Aquaporin-1 (AQP1), also known as Channel-forming integral membrane protein (CHIP), is the first member of the aquaporin water channel family. It plays a role in the transmembrane water transport, especially in kidneys, red blood cells, central nervous system and some epithelial surfaces. Its activity can be blocked by mercurial compounds. AQP1 is associated with so-called Colton blood group antigens.

Subfamily:-Aquaporin">Family: Transporter
Subfamily: Aquaporin

Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB)

IF (1:200 - 1:400), IHC-P (10 ug/ml), WB (1:1000 - 1:4000)

Anti-AQP1 / Aquaporin 1 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml.

Anti-AQP1 / Aquaporin 1 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml.

IF analysis of Aquaporin 1 in rat kidney tissue using a 1 in 200 dilution of AQP1 / Aquaporin 1 antibody. DAPI merge.

16,677 Da

aquaporin 1 (Colton blood group)

aquaporin-1; aquaporin-CHIP; urine water channel; channel-like integral membrane protein, 28-kDa; water channel protein for red blood cells and kidney proximal tubule; aquaporin 1 (channel-forming integral protein, 28kDa, CO blood group)

Aquaporin-1

CHIP28; AQP-1??[Similar Products]

AQP1_HUMAN

Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). This gene encodes an aquaporin which functions as a molecular water channel protein. It is a homotetramer with 6 bilayer spanning domains and N-glycosylation sites. The protein physically resembles channel proteins and is abundant in erythrocytes and renal tubes. The gene encoding this aquaporin is a possible candidate for disorders involving imbalance in ocular fluid movement. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

AQP1: Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Belongs to the MIP/aquaporin (TC 1.A.8) family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter; Transporter, aquaporin family

Chromosomal Location of Human Ortholog: 7p14

Cellular Component: nuclear membrane; brush border membrane; integral to plasma membrane; basolateral plasma membrane; apical part of cell; cytoplasm; apical plasma membrane; plasma membrane; basal plasma membrane; nerve terminal; nucleus; brush border; sarcolemma

Molecular Function: protein binding; potassium channel activity; ephrin receptor binding; water transporter activity; ammonium transmembrane transporter activity; intracellular cGMP activated cation channel activity; glycerol transmembrane transporter activity; potassium ion transmembrane transporter activity; nitric oxide transporter activity; transmembrane transporter activity; water channel activity; glycerol channel activity

Biological Process: cGMP biosynthetic process; glycerol transport; cerebrospinal fluid secretion; wound healing; water transport; cellular response to stress; carbon dioxide transport; negative regulation of caspase activity; sensory perception of pain; pancreatic juice secretion; positive regulation of saliva secretion; odontogenesis; positive regulation of fibroblast proliferation; hyperosmotic salinity response; nitric oxide transport; bicarbonate transport; multicellular organismal water homeostasis; cellular homeostasis; transmembrane transport; potassium ion transport; lipid digestion; lateral ventricle development; response to drug; cellular water homeostasis; secretory granule organization and biogenesis; glomerular filtration; ammonium transport; renal water transport; positive regulation of angiogenesis; camera-type eye morphogenesis; response to estrogen stimulus; adrenocorticotropin hormone secretion; establishment and/or maintenance of actin cytoskeleton polarity; renal water homeostasis; cell volume homeostasis; negative regulation of apoptosis

Disease: Blood Group--colton

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.