Transcobalamin-1; TC-1; Haptocorrin; HC; Protein R; Transcobalamin I; TC I; TCI; TCN1; TC1

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit Ig

Rabbit

This TCN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 406-433 amino acids from the C-terminal region of human TCN1.

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Vial Concentration: 0.5 (lot specific)

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-TCN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This gene encodes a member of the vitamin B12-binding
protein family. This family of proteins, alternatively referred to
as R binders, is expressed in various tissues and secretions. This
protein is a major constituent of secondary granules in neutrophils
and facilitates the transport of cobalamin into cells. [provided by
RefSeq].

Metabolism; Signal Transduction

Western Blot (WB), ELISA (EIA)

WB~~1:1000

TCN1 Antibody (C-term) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the TCN1 antibody detected the TCN1 protein (arrow).

48207

transcobalamin I (vitamin B12 binding protein, R binder family)

transcobalamin-1

Transcobalamin-1

TC1; TC-1; HC; TC I; TCI??[Similar Products]

TCO1_HUMAN

This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This protein is a major constituent of secondary granules in neutrophils and facilitates the transport of cobalamin into cells. [provided by RefSeq, Jul 2008]

TCN1: Vitamin B12-binding protein. Transports cobalamin into cells. Belongs to the eukaryotic cobalamin transport proteins family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 11q11-q12

Cellular Component: extracellular space; extracellular region

Molecular Function: cobalamin binding

Biological Process: vitamin metabolic process; cobalamin metabolic process; cobalamin transport; cobalt ion transport; water-soluble vitamin metabolic process

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Garrod, M.G., et al. Eur J Clin Nutr 64(5):503-509(2010)
Matteini, A.M., et al. J Nutr Health Aging 14(1):73-77(2010)
McGeachie, M., et al. Circulation 120(24):2448-2454(2009)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)

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