Product Name
TCN1, Blocking Peptide
Product Synonym Names
Transcobalamin-1; TC-1; Haptocorrin; HC; Protein R; Transcobalamin I; TC I; TCI; TCN1; TC1
Product Gene Name
TCN1 blocking peptide
[Similar Products]
Product Synonym Gene Name
TC1[Similar Products]
Antibody/Peptide Pairs
TCN1 peptide (MBS9224083) is used for blocking the activity of TCN1 antibody (MBS9210565)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P20061
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Cellular Location
Secreted.
Tissue Location
Produced by the salivary glands of the oral cavity, in response to ingestion of food. Major constituent of secondary granules in neutrophils.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Other Notes
Small volumes of TCN1 blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
TCN1 blocking peptide
Binds vitamin B12 with femtomolar affinity and protects it from the acidic environment of the stomach.
NCBI/Uniprot data below describe general gene information for TCN1. It may not necessarily be applicable to this product.
NCBI Accession #
P20061.2
[Other Products]
UniProt Primary Accession #
P20061
[Other Products]
UniProt Secondary Accession #
Q8WV77; A8KAC5[Other Products]
UniProt Related Accession #
P20061[Other Products]
Molecular Weight
48,207 Da
NCBI Official Full Name
Transcobalamin-1
NCBI Official Synonym Full Names
transcobalamin 1
NCBI Official Symbol
TCN1??[Similar Products]
NCBI Official Synonym Symbols
HC; TC1; TCI; TC-1
??[Similar Products]
NCBI Protein Information
transcobalamin-1
UniProt Protein Name
Transcobalamin-1
UniProt Synonym Protein Names
Haptocorrin; HC; Protein R; Transcobalamin I; TC I; TCI
Protein Family
Transcobalamin
UniProt Gene Name
TCN1??[Similar Products]
UniProt Synonym Gene Names
TC1; TC-1; HC; TC I; TCI??[Similar Products]
UniProt Entry Name
TCO1_HUMAN
NCBI Summary for TCN1
This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This protein is a major constituent of secondary granules in neutrophils and facilitates the transport of cobalamin into cells. [provided by RefSeq, Jul 2008]
UniProt Comments for TCN1
TCN1: Vitamin B12-binding protein. Transports cobalamin into cells. Belongs to the eukaryotic cobalamin transport proteins family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 11q11-q12
Cellular Component: extracellular region; extracellular space
Biological Process: cobalamin metabolic process
Research Articles on TCN1
1. Levels of holotranscobalamin are decreased patients with cobalamin deficiency.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
