Full Product Name
SNX15, CT (SNX15, Sorting nexin-15)
Product Synonym Names
Anti -SNX15, CT (SNX15, Sorting nexin-15)
Product Gene Name
anti-SNX15 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 11; NC_000011.9 (64794880..64808044). Location: 11q12
3D Structure
ModBase 3D Structure for Q9NRS6
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Immunogen
SNX15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 222-251 amino acids from the C-terminal region of human SNX15.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-SNX15 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SNX15 antibody
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. This gene encodes two transcript variants encoding distinct isoforms. [provided by RefSeq].
Product Categories/Family for anti-SNX15 antibody
Antibodies; Abs to SNX (Sorting Nexin) Proteins
Applications Tested/Suitable for anti-SNX15 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-SNX15 antibody
Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
NCBI/Uniprot data below describe general gene information for SNX15. It may not necessarily be applicable to this product.
NCBI Accession #
NP_037438.2
[Other Products]
NCBI GenBank Nucleotide #
NM_013306.4
[Other Products]
UniProt Primary Accession #
Q9NRS6
[Other Products]
UniProt Secondary Accession #
Q9NRS5[Other Products]
UniProt Related Accession #
Q9NRS6[Other Products]
Molecular Weight
38,291 Da[Similar Products]
NCBI Official Full Name
sorting nexin-15 isoform A
NCBI Official Synonym Full Names
sorting nexin 15
NCBI Official Symbol
SNX15??[Similar Products]
NCBI Official Synonym Symbols
HSAF001435
??[Similar Products]
NCBI Protein Information
sorting nexin-15; clone iota unknown protein
UniProt Protein Name
Sorting nexin-15
Protein Family
Sorting nexin
UniProt Gene Name
SNX15??[Similar Products]
UniProt Entry Name
SNX15_HUMAN
NCBI Summary for SNX15
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ADP-ribosylation factor-like 2 (ARL2) gene. [provided by RefSeq, Dec 2010]
UniProt Comments for SNX15
SNX15: May be involved in several stages of intracellular trafficking. Overexpression of SNX15 disrupts the normal trafficking of proteins from the plasma membrane to recycling endosomes or the TGN. Belongs to the sorting nexin family. 2 isoforms of the human protein are produced by alternative splicing.
Chromosomal Location of Human Ortholog: 11q12
Cellular Component: cytoplasmic vesicle membrane; membrane; cytoplasm; nucleolus; cytosol
Molecular Function: phosphoinositide binding
Biological Process: intracellular protein transport
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
