Product Name
Protein Tyrosine Phosphatase, Receptor Type sigma (PTPRS), Polyclonal Antibody
Full Product Name
Protein Tyrosine Phosphatase, Receptor Type sigma (PTPRS)
Product Synonym Names
Anti -Protein Tyrosine Phosphatase, Receptor Type sigma (PTPRS)
Product Gene Name
anti-PTPRS antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
chromosome: 19; Location: 19p13.3
3D Structure
ModBase 3D Structure for Q59FX6
Specificity
Recognizes human Protein Tyrosine Phosphatase, Receptor Type sigma.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Glycerol free.
Immunogen
Synthetic peptide corresponding to aa330-524
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of anti-PTPRS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-PTPRS antibody
This protein is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control of ***** nerve repair.
Product Categories/Family for anti-PTPRS antibody
Antibodies; Abs to Enzymes, Phosphatase
Applications Tested/Suitable for anti-PTPRS antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-PTPRS antibody
Suitable for use in ELISA and Western Blot.
Dilution: Western Blot: 1:500-1:1000
NCBI/Uniprot data below describe general gene information for PTPRS. It may not necessarily be applicable to this product.
UniProt Primary Accession #
Q59FX6
[Other Products]
UniProt Related Accession #
Q13332; Q16343; Q2M3R7; Q59FX6; Q8NHS7; Q9UM81[Other Products]
Molecular Weight
174,656 Da[Similar Products]
NCBI Official Full Name
protein tyrosine phosphatase, receptor type, sigma isoform 3 variant
NCBI Official Synonym Full Names
protein tyrosine phosphatase, receptor type, S
NCBI Official Symbol
PTPRS??[Similar Products]
NCBI Official Synonym Symbols
PTPSIGMA; PTPRS
??[Similar Products]
NCBI Protein Information
receptor-type tyrosine-protein phosphatase S; R-PTP-S; R-PTP-sigma; protein tyrosine phosphatase PTPsigma; receptor-type tyrosine-protein phosphatase sigma; protein tyrosine phosphatase, receptor type, sigma
UniProt Protein Name
Protein tyrosine phosphatase, receptor type, sigma isoform 3 variant
Protein Family
Receptor-type tyrosine-protein phosphatase
UniProt Entry Name
Q59FX6_HUMAN
NCBI Summary for PTPRS
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control of ***** nerve repair. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq]
UniProt Comments for PTPRS
PTPRS: Interacts with LAR-interacting protein LIP.1. Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily. 7 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.1.3.48; Membrane protein, integral; Receptor protein phosphatase, tyrosine; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: integral to plasma membrane
Molecular Function: protein binding; transmembrane receptor protein tyrosine phosphatase activity
Biological Process: corpus callosum development; extracellular matrix organization and biogenesis; spinal cord development; hippocampus development; cerebellum development; cerebral cortex development; cell adhesion
Research Articles on PTPRS
1. The receptor protein tyrosine phosphatase sigma (RPTPsigma) has now been identified as a receptor for inhibitory chondroitin sulfate proteoglycans.
2. Trans-synaptic adhesions between netrin-G ligand-3 (NGL-3) and receptor tyrosine phosphatases LAR, protein-tyrosine phosphatase delta (PTPdelta), and PTPsigma via specific domains regulate excitatory synapse formation.
3. In colorectal tumors, microsatellite repeats mutation rates are higher than the mean mutation frequency
4. Observational study of gene-disease association. (HuGE Navigator)
5. Three SNPs that flank exon 8 are associated with ulcerative colitis. The presence of these SNPs is associated with novel splicing that removes the third immunoglobulin-like domain (exon 9) from the extracellular portion of PTPsigma.
6. SNPs rs1143699, rs4807015, and rs1978237 confer an increased risk of developing type 2 diabetes mellitus.
7. Transient overexpression of the short splice variant 3 of RPTPR
Sigma conferred alpha-LTX induced secretion to hamster insulinoma (HIT-15) cells. In contrast, the long splice variant 2 was inactive in secretion or in a single cell assay.
8. interactions between RPTP-domain1s and RPTP-domain 2s are a common but specific mechanism that is likely to be regulated- domain2s and the wedge structures are crucial determinants of binding specificity, thus regulating cross-talk between RPTPs
Precautions
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