Full Product Name
ARL2 (ADP Ribosylation Factor-Like 2, ARFL2)
Product Synonym Names
Anti -ARL2 (ADP Ribosylation Factor-Like 2, ARFL2)
Product Gene Name
anti-ARL2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 11; NC_000011.9 (64781586..64789656). Location: 11q13
3D Structure
ModBase 3D Structure for P36404
Specificity
Recognizes ARL2 at ~20kD in U937 lysate (expected MW from amino acid sequence according to NP_001658 is 20kD).
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Form/Format
Supplied as a liquid in Tris-saline, pH 7.2, 0.5% BSA, 0.02% sodium azide.
Immunogen
Synthetic peptide of ARL2.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of anti-ARL2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ARL2 antibody
The ADP-ribosylation factor (ARF) genes encode small GTP-binding proteins of the RAS superfamily. ARL2 is a member of a functionally distinct group of ARF-like genes.
Product Categories/Family for anti-ARL2 antibody
Antibodies; Abs to GTPase, Rab, Ras, Rho Proteins
Applications Tested/Suitable for anti-ARL2 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-ARL2 antibody
Suitable for use in ELISA and Western Blot.
Dilution: Western Blot: 1-3ug/ml
NCBI/Uniprot data below describe general gene information for ARL2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001658.2
[Other Products]
NCBI GenBank Nucleotide #
NM_001667.3
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UniProt Primary Accession #
P36404
[Other Products]
UniProt Secondary Accession #
Q9BUK8[Other Products]
UniProt Related Accession #
P36404; Q53YD8[Other Products]
Molecular Weight
20,878 Da[Similar Products]
NCBI Official Full Name
ADP-ribosylation factor-like protein 2 isoform 1
NCBI Official Synonym Full Names
ADP-ribosylation factor-like 2
NCBI Official Symbol
ARL2??[Similar Products]
NCBI Official Synonym Symbols
ARFL2
??[Similar Products]
NCBI Protein Information
ADP-ribosylation factor-like protein 2; OTTHUMP00000230835; OTTHUMP00000230836; OTTHUMP00000230838
UniProt Protein Name
ADP-ribosylation factor-like protein 2
Protein Family
ADP-ribosylation factor-like protein
UniProt Gene Name
ARL2??[Similar Products]
UniProt Entry Name
ARL2_HUMAN
NCBI Summary for ARL2
This gene encodes a small GTP-binding protein of the RAS superfamily which functions as an ADP-ribosylation factor (ARF). The encoded protein is one of a functionally distinct group of ARF-like genes. [provided by RefSeq]
UniProt Comments for ARL2
ARL2: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca(2+)-dependent release of acetylcholine. Required for normal progress through the cell cycle. Belongs to the small GTPase superfamily. Arf family.
Protein type: Mitochondrial; G protein, monomeric; G protein, monomeric, ARF
Chromosomal Location of Human Ortholog: 11q13
Cellular Component: centrosome; mitochondrial intermembrane space; nucleus; lateral plasma membrane
Molecular Function: GTPase activity; protein binding; GDP binding; GTP binding; GTPase inhibitor activity
Biological Process: tubulin folding; centrosome organization and biogenesis; metabolic process; positive regulation of microtubule polymerization; small GTPase mediated signal transduction; maintenance of protein localization in nucleus; cell cycle; regulation of microtubule polymerization
Research Articles on ARL2
1. a novel function of miR-16 targeting ARL2 in modulating proliferation and cell cycle progression.
Precautions
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Disclaimer
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