Product Name
Protein amnionless (Amn), Recombinant Protein
Full Product Name
Recombinant Mouse Protein amnionless (Amn), partial
Product Gene Name
Amn recombinant protein
[Similar Products]
Product Synonym Gene Name
Amn[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
20-362
Sequence
A YKLWVPNTSF DTASNWNQNR TPCAGDAVQF PADKMVSVLV RDSHAISDML LPLDGELVLA SGAALSAAGG DSDPACNPGA PLLFRNPDRF SWLDPHLWSS GTQAPGLFSV DAERVPCSYD DVLFPRDGSF RVALGPGPNP VHVRSVSAVG QTFSRDEDLT AFLASREGRL RFHGSGALRV GSQACTDASG CVCGNAEMLP WICASLLQPL GGRCPQAACQ DPLLPQGQCC DLCGAIVSLT HDPTFDLERY RARLLDLFLK QPQYQGLQVA VSKVLRDAHT EIQVVLVETE HATGAAGQLG HALLQDAVAQ GSVLGIVSAT LRQSGKPMTA DSELNQSSSG AG
3D Structure
ModBase 3D Structure for Q99JB7
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Amn recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Amn recombinant protein
This protein is a type I transmembrane protein. It is thought to modulate bone morphogenetic protein (BMP) receptor function by serving as an accessory or coreceptor, and thus facilitates or hinders BMP binding. It is known that the mouse AMN gene is expressed in the extraembryonic visceral endoderm layer during gastrulation, but it is found to be mutated in amnionless mouse. The encoded protein has sequence similarity to short gastrulation (Sog) and procollagen IIA proteins in Drosophila.
NCBI/Uniprot data below describe general gene information for Amn. It may not necessarily be applicable to this product.
NCBI Accession #
NP_291081.2
[Other Products]
NCBI GenBank Nucleotide #
NM_033603.3
[Other Products]
UniProt Primary Accession #
Q99JB7
[Other Products]
UniProt Secondary Accession #
Q5I0U1; Q99MP9[Other Products]
UniProt Related Accession #
Q99JB7[Other Products]
Molecular Weight
48,696 Da
NCBI Official Full Name
protein amnionless
NCBI Official Synonym Full Names
amnionless
NCBI Official Symbol
Amn??[Similar Products]
NCBI Protein Information
protein amnionless
UniProt Protein Name
Protein amnionless
Protein Family
Protein amnionless
UniProt Gene Name
Amn??[Similar Products]
NCBI Summary for Amn
This gene encodes a type I transmembrane protein. The encoded protein is an essential component of the cubulin receptor complex which is thought to play a role in coordinating growth and patterning of the embryo. This protein is thought to modulate a bone morphogenetic protein (BMP) signaling pathway. A homoygous mutation in the mouse gene results in the lack of an amnion in embryos. Mutations in the human gene are associated with Megaloblastic Anemia-1. [provided by RefSeq, Sep 2015]
UniProt Comments for Amn
Necessary for efficient absorption of vitamin B12 (). Required for normal CUBN-mediated protein transport in the kidney (PubMed:15342463). May direct the production of trunk mesoderm during development by modulating a bone morphogenetic protein (BMP) signaling pathway in the underlying visceral endoderm.
Research Articles on Amn
1. AMN may participate in meiosis in early spermatocytes and in functional differentiation of ***** Leydig cells through the mediation of vitamin B(12) transport in the mouse testes
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
