Product Name
Cubilin (CUBN), Polyclonal Antibody
Full Product Name
Biotin-Linked Polyclonal Antibody to Cubilin (CUBN)
Product Synonym Names
IFCR; MGA1; gp280; Intrinsic Factor Cobalamin Receptor; 460 kDa receptor; Intestinal intrinsic factor receptor; Intrinsic factor-vitamin B12 receptor
Product Gene Name
anti-CUBN antibody
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Matching Pairs
Unconjugated Antibody: Cubilin (CUBN) (MBS2002953)
Biotin Conjugated Antibody: Cubilin (CUBN) (MBS2094486)
Matching Pairs
Biotin Conjugated Antibody: Cubilin (CUBN) (MBS2094486)
Immunogen: Cubilin (CUBN) (MBS2012431)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9JLB4
Concentration
200ug/ml (lot specific)
Immunogen
CUBN (Cys3511~Ser3623)
ISO Certification
Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customera??s specifications, please inquire.
Other Notes
Small volumes of anti-CUBN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-CUBN antibody
Western Blot (WB), Immunohistochemistry (IHC)
NCBI/Uniprot data below describe general gene information for CUBN. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001074553.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001081084.2
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UniProt Primary Accession #
Q9JLB4
[Other Products]
UniProt Secondary Accession #
B1AX10[Other Products]
UniProt Related Accession #
Q9JLB4[Other Products]
Molecular Weight
399,097 Da
NCBI Official Full Name
cubilin
NCBI Official Synonym Full Names
cubilin (intrinsic factor-cobalamin receptor)
NCBI Official Symbol
Cubn??[Similar Products]
NCBI Official Synonym Symbols
AA408369; AL022750; D2Wsu88e
??[Similar Products]
NCBI Protein Information
cubilin
UniProt Protein Name
Cubilin
UniProt Synonym Protein Names
Intrinsic factor-cobalamin receptor
UniProt Gene Name
Cubn??[Similar Products]
UniProt Synonym Gene Names
Ifcr??[Similar Products]
UniProt Comments for CUBN
CUBN: Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. Interaction with AMN controls its trafficking to the plasma membrane and facilitates endocytosis of ligands. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface. Defects in CUBN are a cause of recessive hereditary megaloblastic anemia 1 (RH-MGA1); also known as MGA1 Norwegian type or Imerslund-Grasbeck syndrome (I-GS). RH-MGA1 is due to selective malabsorption of vitamin B12. Defects in vitamin B12 absorption lead to impaired function of thymidine synthase. As a consequence DNA synthesis is interrupted. Rapidly dividing cells involved in erythropoiesis are particularly affected.
Chromosomal Location of Human Ortholog: 2 A1|2 9.86 cM
Cellular Component: apical part of cell; apical plasma membrane; brush border; brush border membrane; clathrin-coated pit; cytoplasm; endocytic vesicle; endoplasmic reticulum; endosome; Golgi apparatus; lysosomal lumen; lysosome; membrane; plasma membrane; protein complex
Molecular Function: calcium ion binding; cobalamin binding; cobalamin transporter activity; drug binding; hemoglobin binding; identical protein binding; metal ion binding; protein binding; protein homodimerization activity; receptor activity
Biological Process: cholesterol metabolic process; cobalamin transport; hemoglobin import; in utero embryonic development; lipid metabolic process; lipoprotein transport; protein transport; receptor-mediated endocytosis; response to nutrient; steroid metabolic process; transport
Research Articles on CUBN
1. In ***** mouse testes, strong Cubn immunoreactivity was found in the elongating spermatids. In Sertoli cells and peritubular cells, Cubn immunoreactivity was weak throughout the testis development. In the inter-stitium, Cubn immunoreactivity was found in foetal Leydig cells, was weak to negligible in the stem cells and progenitor Leydig cells and was strong in immature and ***** Leydig cells.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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