Product Name
Cubilin (CUBN), Antibody Pair Kit
Full Product Name
Cubilin (CUBN) Antibody Pair Kit (with Standard)
Product Synonym Names
IFCR; MGA1; gp280; Intrinsic Factor Cobalamin Receptor; 460 kDa receptor; Intestinal intrinsic factor receptor; Intrinsic factor-vitamin B12 receptor
Product Gene Name
CUBN antibody pair kit
[Similar Products]
Matching Pairs
Antibody: Cubilin (CUBN) (MBS2101634)
Pairing: Cubilin (CUBN) (MBS2101634)
Comments: Matched antibody pair kit containing antibody/standard combination
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Request for Current Manual Insert
Request Current Manual
3D Structure
ModBase 3D Structure for Q9JLB4
Samples
Tissue Homogenates, Cell Lysates and Other Biological Fluids
Detection Range
0.625-40ng/mL
Standard
Recombinant CUBN (Lyophilized, 1 vial-10ug)
Capture Antibody
Rabbit polyclonal antibody (Liquid, 1 vial-400mug/800muL)
Detection Antibody
Biotinylated Rabbit polyclonal antibody (Liquid, 1 vial-100mug/500muL)
Producte Usage
Raw materials can be used for preparation of 5x96T or 10x96T ELISA Kits.
Antibody Support Pack
Antibody Support Pack (Buffer Pack) is sold separately as catalog #MBS2090685
ISO Certification
Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customera??s specifications, please inquire.
Product Note
Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual.
Other Notes
Small volumes of CUBN antibody pair kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for CUBN antibody pair kit
Signal transduction; Metabolic pathway; Nutrition metabolism; Dermatology
Applications Tested/Suitable for CUBN antibody pair kit
ELISA (EIA), Chemiluminescence Immunoassays (CLIA), ELISPOT, Luminex
NCBI/Uniprot data below describe general gene information for CUBN. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001074553.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001081084.2
[Other Products]
UniProt Primary Accession #
Q9JLB4
[Other Products]
UniProt Secondary Accession #
B1AX10[Other Products]
UniProt Related Accession #
Q9JLB4[Other Products]
Molecular Weight
399,097 Da
NCBI Official Full Name
cubilin
NCBI Official Synonym Full Names
cubilin (intrinsic factor-cobalamin receptor)
NCBI Official Symbol
Cubn??[Similar Products]
NCBI Official Synonym Symbols
AA408369; AL022750; D2Wsu88e
??[Similar Products]
NCBI Protein Information
cubilin
UniProt Protein Name
Cubilin
UniProt Synonym Protein Names
Intrinsic factor-cobalamin receptor
UniProt Gene Name
Cubn??[Similar Products]
UniProt Synonym Gene Names
Ifcr??[Similar Products]
UniProt Comments for CUBN
Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. Interaction with AMN controls its trafficking to the plasma membrane and facilitates endocytosis of ligands. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface.
Research Articles on CUBN
1. In ***** mouse testes, strong Cubn immunoreactivity was found in the elongating spermatids. In Sertoli cells and peritubular cells, Cubn immunoreactivity was weak throughout the testis development. In the inter-stitium, Cubn immunoreactivity was found in foetal Leydig cells, was weak to negligible in the stem cells and progenitor Leydig cells and was strong in immature and ***** Leydig cells.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
