Human ADP-ribosylation factor-like protein 2 (ARL2) ELISA kit; ARFL2; ; ADP-ribosylation factor-like 2

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of ARL2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9327438 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the ADP-ribosylation factor-like 2 (ARL2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ARL2. The ELISA analytical biochemical technique of the MBS9327438 kit is based on ARL2 antibody-ARL2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ARL2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ARL2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

20,878 Da

ADP-ribosylation factor-like 2

ADP-ribosylation factor-like protein 2

ADP-ribosylation factor-like protein 2

ARL2_HUMAN

This gene encodes a small GTP-binding protein of the RAS superfamily which functions as an ADP-ribosylation factor (ARF). The encoded protein is one of a functionally distinct group of ARF-like genes. [provided by RefSeq, Jul 2008]

ARL2: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca(2+)-dependent release of acetylcholine. Required for normal progress through the cell cycle. Belongs to the small GTPase superfamily. Arf family.

Protein type: G protein, monomeric; Mitochondrial; G protein, monomeric, ARF

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: centrosome; mitochondrial intermembrane space; nucleus; lateral plasma membrane

Molecular Function: GTPase activity; protein binding; GDP binding; GTP binding; GTPase inhibitor activity

Biological Process: tubulin folding; metabolic process; centrosome organization and biogenesis; positive regulation of microtubule polymerization; small GTPase mediated signal transduction; maintenance of protein localization in nucleus; cell cycle; regulation of microtubule polymerization

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