Product Name
Bardet-Biedl syndrome 2 protein homolog (Bbs2), Recombinant Protein
Full Product Name
Recombinant Rat Bardet-Biedl syndrome 2 protein homolog (Bbs2)
Product Gene Name
Bbs2 recombinant protein
[Similar Products]
Product Synonym Gene Name
Bbs2[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-721aa, full length protein
Sequence
MLLPVFTLKL RHKISPRMVA IGRYDGTHPC LAAATQAGKV FIHNPHMRSQ HFSTSRVFQS PLESDVSLLN INQTVSCLGA GVLNPELGYD TLLVGTQTSL LAYDIYNNSD LFYREVADGA NALVLGTLGD IAPPLAIIGG NCALQGFDHE GNDLFWTVTG DNVHSLALCD FDGDGKSELL VGSEDFDIRV FKEDEIVAEM TETEIVTSLC PMYGSRFGYA LSNGTVGVYD KTARYWRIKS KNHAMSIHAF DINSDGVCEL ITGWSNGKVD ARSDRTGEVI FKDNFSSAVA GVVEGDYRMD GHVQLICCSV DGEIRGYLPG TAEMKGNLLD TSVEQGLIRE LSQKKQNLLL ELRNYEENTK AELSSPLNEA DGQKGIIPAN TKLHTALSVN LGNDAQDAHA ELRISTSNDT IIRAVLIFAE GIFAGESHVV HPSTHNLSSS IRVPITPPKD VPVDLHLKTF VGYRSSTQFH VFELIRQLPR FTMYALTSPD AASEPVSFVN FIVVERAQRM VTWLNQNFLL PEDSNIQNAP FHVCFTSLRN GGQLYIKMKP SGEITVNTDD IDLAGDIIQS MASFFAIEDL QVEADFPVYF EELRKVLLKV DEYHSVHQKL SANMADNSNL IRSLLVRAED ARLMRDMKTM KTRYMELYDL NKDLLNGYKI RCNNHTELLG NLKAVNQAIQ RAGRLRVGKP KNQVISACRD AIRSNNINTL FRIMRVGTAP S
3D Structure
ModBase 3D Structure for Q99MH9
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Bbs2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for Bbs2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_446070.1
[Other Products]
NCBI GenBank Nucleotide #
NM_053618.1
[Other Products]
UniProt Primary Accession #
Q99MH9
[Other Products]
UniProt Related Accession #
Q99MH9[Other Products]
Molecular Weight
79,918 Da
NCBI Official Full Name
Bardet-Biedl syndrome 2 protein homolog
NCBI Official Synonym Full Names
Bardet-Biedl syndrome 2
NCBI Official Symbol
Bbs2??[Similar Products]
NCBI Protein Information
Bardet-Biedl syndrome 2 protein homolog
UniProt Protein Name
Bardet-Biedl syndrome 2 protein homolog
Protein Family
Bardet-Biedl syndrome 2 protein
UniProt Gene Name
Bbs2??[Similar Products]
UniProt Comments for Bbs2
The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization ().
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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