ARL6; ADP-ribosylation factor-like 6; BBS3; 1110018H24Rik; 2210411E14Rik; ADP-ribosylation factor-like protein 6; ADP-ribosylation-like factor homolog ARL6; bardet-Biedl syndrome 3 protein; ARL6 antibody; ADP-ribosylation factor-like 6 antibody; BBS3 antibody; 1110018H24Rik antibody; 2210411E14Rik antibody; ADP-ribosylation factor-like protein 6 antibody; ADP-ribosylation-like factor homolog ARL6 antibody; bardet-Biedl syndrome 3 protein antibody; Arl6 / BBS3 (mouse)

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Goat

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul (lot specific)

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Manufactured in an ISO 9001:2008 Certified Laboratory.

Small volumes of anti-Arl6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Peptide ELISA (EIA)

Peptide ELISA: Antibody detection limit dilution 1: 16000.
Western Blot: Preliminary experiments gave an approx 33kDa band in Mouse Brain lysates after 1ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 21. 0kDa according to NP_062639.3. The 33kDa band was successfully blocked by incubation with the immunizing peptide.

21,778 Da

ADP-ribosylation factor-like 6

ADP-ribosylation factor-like protein 6

ADP-ribosylation factor-like protein 6

Bbs3??[Similar Products]

ARL6_MOUSE

ARL6: Involved in membrane protein trafficking at the base of the ciliary organelle. Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia. May regulate cilia assembly and disassembly and subsequent ciliary signaling events such as the Wnt signaling cascade. Isoform 2 may be required for proper retinal function and organization. Defects in ARL6 are a cause of Bardet-Biedl syndrome type 3 (BBS3). Bardet-Biedl syndrome (BBS) is a genetically heterogeneous disorder characterized by usually severe pigmentary retinopathy, early onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation. Secondary features include diabetes mellitus, hypertension and congenital heart disease. Defects in ARL6 are the cause of retinitis pigmentosa type 55 (RP55). RP55 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. Belongs to the small GTPase superfamily. Arf family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: G protein; G protein, monomeric; G protein, monomeric, ARF

Cellular Component: cell projection; cilium; cytoplasm; cytoskeleton; cytosol; intracellular; membrane; plasma membrane

Molecular Function: GTP binding; metal ion binding; nucleotide binding; protein binding

Biological Process: brain development; cell projection organization and biogenesis; cilium biogenesis; intermembrane transport; protein amino acid ADP-ribosylation; protein transport; Ras protein signal transduction; regulation of smoothened signaling pathway; small GTPase mediated signal transduction; transport; Wnt receptor signaling pathway

Disease: Bardet-biedl Syndrome 1

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.