Product Name
Metalloendopeptidase homolog PEX (Phex
), Recombinant Protein
Full Product Name
Recombinant Mouse Metalloendopeptidase homolog PEX (Phex)
Product Gene Name
Phex
recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-749aa; full length protein
Sequence
MEAETGSTME TGKGTNRGIR IALALFIGGT LVLGTLLFLV SQGLLSFQAK QEYCLKPECI EAAAAIMSKV NLSVDPCENF FRFACDGWIS NNPIPEDMPS YGVYPWLRHN VDLKLKALLE KSVSRRRDTE AVQKAKILYS SCMNEKAIEK ADAKPLLHIL RHSPFRWPVL EANIGPEGVW SERKFSLLQT LATFRGQYSN SVFIRLYVSP DDKASNEHIL KLDQATLSLA VREDFLDNTT EAKSYRDALY KFMVDTAVLL GANSSRAEHD MKSVLRLEIK IAEIMIPHEN RTSEAMYNKM NISELSAMIP QFDWLGYIKK VIDTRLYPHL KDIGPSENVV VRVPQYFKDL FRILGAERKK TIANYLVWRM VYSRIPNLSR RFQYRWLEFS RVIQGTTTLL PQWDKCVNFI ESALPYVVGK MFVNVHFQED KKEMMEELIE GVRWAFIDML EKENEWMDAG TKRKAQEKAR AVLAKVGYPE FIMNDTYVNE DLKAIKFSES DYFGNVLQTR KYLAQSDFFW LRKAVPKTEW FTNPTTVNAF YSASTNQIRF PAGELQKPFF WGTEYPRSLS YGAIGVIVGH EFTHGFDNNG RKYDKNGNLD PWWSVESEEK FKEKTKCMIN QYSNYYWKKA GLNVKGKRTL GENIADNGGL REAFRAYRKW INDRRQGVEE PLLPGITFTN NQLFFLSYAH VRCNSYRPEA AREQVQIGAH SPPQFRVNGA ISNFEEFQKA FNCPRNSTMN RGADSCRLW
3D Structure
ModBase 3D Structure for P70669
Host
Cell Free Expression
Form/Format
Liquid containing glycerol
Species
Mus musculus (Mouse)
Storage Buffer
Tris-based buffer, 50% glycerol.
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Phex
recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Phex
recombinant protein
This is a recombinant transmembrane protein expressed in a cell-free expression system.
Product Categories/Family for Phex
recombinant protein
Transmembrane Protein
NCBI/Uniprot data below describe general gene information for Phex
. It may not necessarily be applicable to this product.
NCBI Accession #
NP_035207.1
[Other Products]
NCBI GenBank Nucleotide #
NM_011077.2
[Other Products]
UniProt Primary Accession #
P70669
[Other Products]
UniProt Secondary Accession #
P97439[Other Products]
UniProt Related Accession #
P70669[Other Products]
Molecular Weight
86,419 Da
NCBI Official Full Name
metalloendopeptidase homolog PEX
NCBI Official Synonym Full Names
phosphate regulating endopeptidase homolog, X-linked
NCBI Official Symbol
Phex??[Similar Products]
NCBI Official Synonym Symbols
Gy; Hyp; PEX; HPDR; HPDR1
??[Similar Products]
NCBI Protein Information
metalloendopeptidase homolog PEX
UniProt Protein Name
Metalloendopeptidase homolog PEX
UniProt Synonym Protein Names
Phosphate regulating neutral endopeptidase; Vitamin D-resistant hypophosphatemic rickets protein; X-linked hypophosphatemia protein; HYP
Protein Family
Metalloendopeptidase
UniProt Gene Name
Phex??[Similar Products]
UniProt Synonym Gene Names
Hyp; Pex; HYP??[Similar Products]
UniProt Entry Name
PHEX_MOUSE
UniProt Comments for Phex
PHEX: Probably involved in bone and dentin mineralization and renal phosphate reabsorption. Defects in PHEX are a cause of hypophosphatemic rickets, X-linked dominant (XLHR). XLHR is an X-linked dominant disorder characterized by impaired phosphate uptake in the kidney, which is likely to be caused by abnormal regulation of sodium phosphate cotransport in the proximal tubules. Clinical manifestations include skeletal deformities, growth failure, craniosynostosis, paravertebral calcifications, pseudofractures in lower extremities, and muscular hypotonia with onset in early childhood. X-linked hypophosphatemic rickets is the most common form of hypophosphatemia with an incidence of 1 in 20000. Belongs to the peptidase M13 family.
Protein type: EC 3.4.24.-; Protease; Membrane protein, integral
Cellular Component: endoplasmic reticulum; Golgi apparatus; perinuclear region of cytoplasm
Biological Process: bone mineralization; organophosphate metabolic process; proteolysis
Research Articles on Phex
1. the phex mutation may create the lower set point for extracellular phosphate concentrations in a murine model of X-linked hypophosphatemia
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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