Full Product Name
MEPE antibody - middle region
Product Gene Name
anti-MEPE antibody
[Similar Products]
Product Synonym Gene Name
OF45[Similar Products]
Antibody/Peptide Pairs
MEPE peptide (MBS3228274) is used for blocking the activity of MEPE antibody (MBS3203304)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Immunogen Sequence
Synthetic peptide located within the following region: LPGREGNRVD AGSQNAHQGK VEFHYPPAPS KEKRKEGSSD AAESTNYNEI
3D Structure
ModBase 3D Structure for Q9NQ76
Species Reactivity
Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
Purity/Purification
Affinity Purified
Form/Format
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Homology
Dog: 86%; Guinea Pig: 86%; Horse: 93%; Human: 100%; Mouse: 93%; Rabbit: 93%; Rat: 93%
Immunogen
The immunogen is a synthetic peptide directed towards the middle region of human MEPE
Preparation and Storage
For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Other Notes
Small volumes of anti-MEPE antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-MEPE antibody
This is a rabbit polyclonal antibody against MEPE. It was validated on Western Blot
Target Description: MEPE seems to play a role in mineralization.
Product Categories/Family for anti-MEPE antibody
Polyclonal; Cell Biology; Various;
Applications Tested/Suitable for anti-MEPE antibody
Western Blot (WB)
Western Blot (WB) of anti-MEPE antibody
WB Suggested Anti-MEPE Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: Hela cell lysate
NCBI/Uniprot data below describe general gene information for MEPE. It may not necessarily be applicable to this product.
NCBI Accession #
NP_064588
[Other Products]
NCBI GenBank Nucleotide #
NM_020203
[Other Products]
UniProt Primary Accession #
Q9NQ76
[Other Products]
UniProt Related Accession #
Q9NQ76[Other Products]
NCBI Official Full Name
matrix extracellular phosphoglycoprotein isoform a
NCBI Official Synonym Full Names
matrix extracellular phosphoglycoprotein
NCBI Official Symbol
MEPE??[Similar Products]
NCBI Official Synonym Symbols
OF45
??[Similar Products]
NCBI Protein Information
matrix extracellular phosphoglycoprotein
UniProt Protein Name
Matrix extracellular phosphoglycoprotein
UniProt Synonym Protein Names
Osteoblast/osteocyte factor 45
Protein Family
Matrix extracellular phosphoglycoprotein
UniProt Gene Name
MEPE??[Similar Products]
UniProt Synonym Gene Names
OF45??[Similar Products]
UniProt Entry Name
MEPE_HUMAN
NCBI Summary for MEPE
This gene encodes a secreted calcium-binding phosphoprotein that belongs to the small integrin-binding ligand, N-linked glycoprotein (SIBLING) family of proteins. Members of this family are components of the extracellular matrix of bone and dentin and regulate bone mineralization. Deficiency of a similar protein in mouse results in increased bone mass. Mice lacking this gene are resistant to aging-related trabecular bone loss. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
UniProt Comments for MEPE
MEPE: Promotes renal phosphate excretion and modulates mineralization. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 4q21.1
Cellular Component: proteinaceous extracellular matrix
Molecular Function: protein binding; extracellular matrix structural constituent
Biological Process: negative regulation of bone mineralization; biomineral formation; regulation of bone remodeling; skeletal development
Research Articles on MEPE
1. Results indicate an association of MEPE gene inactivation with decreased survival after DNA damage.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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