Full Product Name
MEPE Rabbit Polyclonal
Product Gene Name
anti-MEPE antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Purity/Purification
>=95% as determined by SDS-PAGE
Immunogen Affinity Purified
Immunogen
Matrix extracellular phosphoglycoprotein
Preparation and Storage
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-MEPE antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-MEPE antibody
ELISA (EIA), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for MEPE. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001278112.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001291183.1
[Other Products]
UniProt Secondary Accession #
A1A4X9; A8MTA3; D2CFR4; F5H5C5[Other Products]
UniProt Related Accession #
Q9NQ76[Other Products]
Molecular Weight
45,291 Da
NCBI Official Full Name
matrix extracellular phosphoglycoprotein isoform c
NCBI Official Synonym Full Names
matrix extracellular phosphoglycoprotein
NCBI Official Symbol
MEPE??[Similar Products]
NCBI Official Synonym Symbols
OF45
??[Similar Products]
NCBI Protein Information
matrix extracellular phosphoglycoprotein
UniProt Protein Name
Matrix extracellular phosphoglycoprotein
UniProt Synonym Protein Names
Osteoblast/osteocyte factor 45; OF45
Protein Family
Matrix extracellular phosphoglycoprotein
UniProt Gene Name
MEPE??[Similar Products]
UniProt Synonym Gene Names
OF45??[Similar Products]
UniProt Entry Name
MEPE_HUMAN
NCBI Summary for MEPE
This gene encodes a secreted calcium-binding phosphoprotein that belongs to the small integrin-binding ligand, N-linked glycoprotein (SIBLING) family of proteins. Members of this family are components of the extracellular matrix of bone and dentin and regulate bone mineralization. Deficiency of a similar protein in mouse results in increased bone mass. Mice lacking this gene are resistant to aging-related trabecular bone loss. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
UniProt Comments for MEPE
MEPE: Promotes renal phosphate excretion and modulates mineralization. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 4q21.1
Cellular Component: proteinaceous extracellular matrix
Molecular Function: extracellular matrix structural constituent; protein binding
Biological Process: biomineral formation; negative regulation of bone mineralization; regulation of bone remodeling; skeletal development
Research Articles on MEPE
1. Results indicate an association of MEPE gene inactivation with decreased survival after DNA damage.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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