Human Sodium/calcium exchanger 1 (SLC8A1) ELISA kit; DKFZp779F0871; FLJ37694; FLJ43417; MGC119581; NCX1; Na+/Ca++ exchanger; Na+/Ca2+ exchanger; OTTHUMP00000128378; OTTHUMP00000201569; OTTHUMP00000201570; OTTHUMP00000201587; OTTHUMP00000201589; solute carrier family 8 (sodium/calcium exchanger); member 1

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of SLC8A1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9316727 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the solute carrier family 8 (sodium/calcium exchanger), member 1 (SLC8A1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing SLC8A1. The ELISA analytical biochemical technique of the MBS9316727 kit is based on SLC8A1 antibody-SLC8A1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect SLC8A1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, SLC8A1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

108,547 Da

solute carrier family 8 (sodium/calcium exchanger), member 1

sodium/calcium exchanger 1; Na+/Ca++ exchanger; Na+/Ca2+ exchanger; Na(+)/Ca(2+)-exchange protein 1; solute carrier family 8 member 1

Sodium/calcium exchanger 1

CNC; NCX1??[Similar Products]

NAC1_HUMAN

In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.[supplied by OMIM, Apr 2004]

NCX1: Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores. Belongs to the sodium/potassium/calcium exchanger family. SLC8 subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Transporter, SLC family; Membrane protein, multi-pass; Transporter; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2p22.1

Cellular Component: basolateral plasma membrane; integral to plasma membrane; T-tubule; plasma membrane; Z disc; sarcolemma

Molecular Function: calmodulin binding; metal ion binding; cytoskeletal protein binding; ankyrin binding; calcium:sodium antiporter activity

Biological Process: heart morphogenesis; cellular sodium ion homeostasis; embryonic placenta development; regulation of heart rate; vascular smooth muscle contraction; post-embryonic development; calcium ion homeostasis; cardiac muscle cell development; muscle contraction; reduction of cytosolic calcium ion concentration; embryonic heart tube development; ion transport; muscle fiber development; blood coagulation; transmembrane transport; regulation of the force of heart contraction; cardiac muscle contraction

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