Product Name
Sodium/calcium exchanger 1 (SLC8A1), Recombinant Protein
Full Product Name
Recombinant Guinea pig Sodium/calcium exchanger 1 (SLC8A1), partial
Product Gene Name
SLC8A1 recombinant protein
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
33-970
Sequence
ETEMVEEGNE TGECTGSYYC KKGVILPIWE PQDPSFGDKI ARATVYFVAM VYMFLGVSII ADRFMSSIEV ITSQEKEITI KKPNGETTKT TVRIWNETVS NLTLMALGSS APEILLSVIE VCGHNFTAGD LGPSTIVGSA AFNMFIIIAL CVYVVPDGET RKIKHLRVFF VTAAWSIFAY TWLYIILSVI SPGVVEVWEG LLTFFFFPIC VVFAWVADRR LLFYKYVYKR YRAGKQRGMI IEHEGDRPSS KTEIEMDGKV VNSHVENFLD GALVLEVDER DQDDEEARRE MARILKELKQ KHPEKEIEQL IELANYQVLS QQQKSRAFYR IQATRLMTGA GNILKRHAAD QARKAVSMHE VNTEVAENDP VSKIFFEQGT YQCLENCGTV ALTIIRRGGD LTNTVFVDFR TEDGTANAGS DYEFTEGTVV FKPGETQKEI RVGIIDDDIF EEDENFLVHL SNVKVSSEAS EDGILEANHI STLACLGSPS TATVTIFDDD HAGIFTFEEP VTHVSESIGI MEVKVLRTSG ARGNVIVPYK TIEGTARGGG EDFEDTCGEL EFQNDEIVKT ISVKVIDDEE YEKNKTFFLE IGEPRLVEMS EKKALLLNEL GGFTITGKHL YGQPVLRKVH ARDHPIPSTV ITIADEYDDK QPLTSKEEEE RRIAELGRPI LGEHTKLEVI IEESYEFKST VDKLIKKTNL ALVVGTNSWR EQFIEAITVS AGEDDDDDEC GEEKLPSCFD YVMHFLTVFW KVLFAFVPPT EYWNGWACFI VSILMIGLLT AFIGDLASHF GCTIGLKDSV TAVVFVALGT SVPDTFASKV AATQDQYADA SIGNVTGSNA VNVFLGIGVA WSIAAIYHAA NGEQFKVSPG TLAFSVTLFT IFAFINVGVL LYRRRPEIGG ELGGPRTAKL LTSCLFVLLW LLYIFFSSLE AYCHIKGF
3D Structure
ModBase 3D Structure for P48766
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Species
Cavia porcellus (Guinea pig)
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of SLC8A1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for SLC8A1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001166490.1
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NCBI GenBank Nucleotide #
NM_001173019.1
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UniProt Primary Accession #
P48766
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UniProt Related Accession #
P48766[Other Products]
Molecular Weight
108,072 Da
NCBI Official Full Name
sodium/calcium exchanger 1
NCBI Official Symbol
Slc8a1??[Similar Products]
NCBI Official Synonym Symbols
NCX1
??[Similar Products]
NCBI Protein Information
sodium/calcium exchanger 1
UniProt Protein Name
Sodium/calcium exchanger 1
UniProt Synonym Protein Names
Na(+)/Ca(2+)-exchange protein 1; Solute carrier family 8 member 1
Protein Family
Sodium/calcium exchanger
UniProt Gene Name
SLC8A1??[Similar Products]
UniProt Comments for SLC8A1
Mediates the exchange of one Ca2+ ion against three to four Na+ ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca2+ levels and Ca2+-dependent cellular processes (PubMed:7986817). Contributes to Ca2+ transport during excitation-contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca2+ levels due to release of Ca2+ stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca2+ from the cell during the next phase, so that cytoplasmic Ca2+ levels rapidly return to baseline. Required for normal embryonic heart development and the onset of heart contractions ().
Research Articles on SLC8A1
1. NCX is an important determinant for premature ventricular activity in a drug-induced model of Andersen-Tawil syndrome.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
